Harvard Health Ad Watch: What you should know about direct-to-consumer ads

If you’re like most people, you’ve seen a ton of direct-to-consumer (DTC) drug ads in recent years. They’re all over television, in magazines, online, on billboards, and slapped on the sides of buses, promoting treatments for arthritis, cancer, heartburn, psoriasis, flagging memory — and more. The deluge of drug ads can be overwhelming. Worse, the information is often incomplete, biased, or confusing. That’s why we’re launching the Harvard Health Ad Watch series to highlight some benefits and problems with health product advertisements. We’ll focus on the evidence behind the ads and show you how — and why — to view them with a skeptical eye. This post briefly explains direct-to-consumer advertising and FDA regulation, as well as rationales and potential drawbacks for these ads. It also alerts you to words to consider very carefully when advertisers clamor for your attention. In later blogs, we’ll analyze some of the most popular health product ads. How common are DTC ads for health products? Almost every country in the world bans DTC ads for health products like medications and procedures. Years ago in the US, drug ads were directed primarily at doctors. But in 1997 the FDA eased restrictions to allow pharmaceutical companies to advertise directly to consumers. With restraints lifted, spending on prescription drug ads soared to more than $6 billion a year (and rising). Do the ads work? Yes, indeed! Estimates suggest ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Drugs and Supplements Men's Health Women's Health Source Type: blogs

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Publication date: Available online 23 September 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Vincent Laudenbach, Aude Charollais, Sophie Radi, Marie-Hélène Stumpf, Anne Vincent, Ingrid Kaltwasser, Tiphaine Tomczyk, Jacques Benichou, Philippe Leroux, Stéphane Marret
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
In this study, novel hollow gold nanoparticles (HGNPs) were used as drug carriers, and in order to improve the targeting ability of HGNPs to a lung tumor site, polyoxyethylene sorbitol oleate (PSO) was chosen here as a target ligand since it can be specifically recognized by the low-density lipoprotein (LDL) receptor which is usually over expressed on A549 lung cancer cells. In this way, a PSO-modified doxorubicin-loaded HGNP drug delivery system (PSO-HGNPs-DOX) was constructed and its physicochemical properties, photothermal conversion ability, and drug release of PSO-HGNPs-DOX was investigated. Further, the effects of tr...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
CONCLUSIONS: This method has wide-scale application prospects in the identification of metabolites. Considering that limited research has been conducted in this area, this study proposes metabolic pathways to further understand mechanisms of isochlorogenic acid A and the forms that are truly effective in vivo. PMID: 32964757 [PubMed - as supplied by publisher]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Authors: Hong D, Zhao HM Abstract Under the hydrothermal reaction condition, we prepared a new 3D Eu(III)-based coordination polymer (CP) [Eu(H2-DHBDC)0.5(DHBDC)0.5 (H2O)2]n·H2O (1, H4-DHBDC = 2,5-dihydroxy-1,4-terephthalic acid). Furthermore, we assessed the inhibitory influence on cervical cancer cells of this compound. Firstly, for testing the anti-viability of the compound against cervical cancer cells, the Cell Counting Kit-8 (CCK-8) assay was carried out. Then reactive oxygen species (ROS) detection kit was used to determine the ROS accumulation in the cervical cancer cells. Finally, after the Annexin ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Conclusion: IL-23 inhibitors are safe and efficacious therapeutic options for patients with psoriasis and should be considered as a potential first-line therapy alone or in combination with topical medications, phototherapy, and other systemic non-biologic agents. Consideration should be given to the evidence-based guidelines of global dermatologic organizations to help guide therapeutic decisions. PMID: 32962478 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Lin L, Xu X, Yu Y, Ye H, He X, Chen S, Chen X, Shao Z, Chen P Abstract Objective: There were some clinical studies on GLP-1R agonist liraglutide therapy for psoriasis patients with type 2 diabetes, but there is a lack of randomized controlled trials and the mechanism of which remains unclear.Method: A total of 25 psoriasis patients with type 2 diabetes were randomized 1: 1 divided into the control group (n = 13) or liraglutide group (n = 12) for 12 weeks. We determined the PASI, the DLQI, histopathology of psoriasis skin, and the expression of IL-17, IL-23, and TNF-α in th...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Marques E, Paluch Z, Boháč P, Slanař O, Běláček J, Hercogová J Abstract INTRODUCTION: Understanding how different comorbidities and epidemiological factors are related to psoriasis severity can help us estimating patients' clinical outcome. AIM: Establish possible prognostic factors of severe psoriasis. METHODS: Three groups of patients were included: 118 were on topical therapy, 83 used conventional systemic drugs and 112 were treated with biological agents. Based of the fact that patients on topical therapy have a lower grade of disease severity than patients treated syst...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Lam PH, Hon KL, Leung K, Leong KF, Li CK, Leung TF Abstract BACKGROUND: Atopic eczema (AE) is a common relapsing inflammatory skin disease in children which is often associated with chronicity and poor quality of life. Unlike atopic asthma, control of AE is seldom assessed in therapeutics. AIM: To investigate the utility of a Traffic Light Control (TLC) system as a measurement/assessment of self-perceived eczema control. METHODS: This is a prospectively study of all Chinese children (aged 6 to 18 years old) with eczema attending the paediatric dermatology clinic of a tertiary hospital from Jan to J...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
CONCLUSION: SO remains a threatening clinical diagnosis that poses diagnostic and therapeutic challenges. It can be triggered post-traumatic, but also any intraocular surgery. This should be taken into account when assessing the indication for intraocular eye surgery, especially in eyes with reduced visual outcome. PMID: 32967030 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Conclusion: Mitigation of these effects by identifying subjects at risk and promoting dopaminergic homeostasis to help regulate stress-relative hypodopaminergia, attenuate fears, and prevent subsequent unwanted drug and non-drug RDS type addictive behaviors seems prudent. PMID: 32957797 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
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