Expert opinion: criteria for second-line treatment failure in patients with multiple sclerosis

ConclusionsExperts compared therapeutic attitudes and practices regarding second-line treatment failure between French regions. They identified convergences that were used to propose a national agreement on second-line treatment failure criteria, which should be evaluated in real-life prospective cohorts.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: Available online 5 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ting Wang, Zhiyun Lian, Xi Wu, Yazhuo Kong, Dr Hongyu Zhou, Min WeiAbstractNeuromyelitis optica (NMO) is a disease characterised by severe relapses of optic neuritis and longitudinally extensive transverse myelitis and it has a strong female predilection. Pain is one of the most typical symptom in NMO. However, few studies have been conducted to examine the neuropathic pain mechanism of NMO patients or gender-specific effects using magnetic resonance imaging technique. A total of 38 female patients with NMO, 28 with ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsIn this cohort of patients with newly diagnosed CIS and RRMS, fatigue scores were associated with mood, disease impact on daily life and quality of life as well as with alterations of attentive functions. Study results indicate that subjective fatigue scores are not well reflected by some commonly used and objectively measurable disease parameters like EDSS, T2 lesions and NFL levels.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We present 2 cases of paraplegia due to NMO with rehabilitation outcome. Patient concerns: The first case corresponds to a 65-year-old woman with NMO presented with C4 incomplete American Spinal Injury Association (ASIA) scale D, and the second case is a 41-year-old woman with NMO presented with C1 incomplete ASIA-C. Diagnoses: Two cases were confirmed by positive anti-aquaporin-4 antibody and presence of T2-weighted hyperintense lesion in spinal cord on magnetic resonance imaging. Intervention: The first patient planned for focusing on left hand fine motor training through occupational therapy by strengthening an...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
AbstractFew studies evaluated coping strategies in people with multiple sclerosis (pwMS) in relation to annualized relapse rate (ARR) and lesion load (LL). Overall, results might have been influenced by the inclusion of depressed patients. To investigate the coping strategies and their association to disease activity, we studied relapsing –remitting pwMS accurately selected to avoid the confounding effect of depression. Sixty-seven relapsing–remitting pwMS and 67 healthy subjects (HS) underwent to Coping Orientation to Problems Experienced (I-COPE) and Coping Inventory for Stressful Situation (CISS) and Beck De...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Conclusion: The observed results revealed that the ZytuxTM could have a positive and significant effect on all types of MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionThis is the first Egyptian study to show that infratentorial lesions, confluent brain lesions and T1 hypointense lesions are conventional MRI parameters that correlate with the degree of disability in Egyptian MS patients.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSION: Effective treatment of NBD improves the quality of life of patients and reduces the incidence of bladder disorders (LE 4). PMID: 31521507 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
ConclusionMS in Kuwait seems to have an earlier age at onset. There is significant gender difference in mental health impairment among patients. Future interventions should be directed toward women, low-income, and non-Kuwaiti-Arabs. The estimated prevalence is based on self-reported data, tertiles as cut-off points, and hence should be interpreted with caution. PDQ and MHI are MSQOLI scales used as screening tools that don't correlate well with an objective test and shouldn't replace objective measures of physical and cognitive function tests including expanded disability status scale or magnetic resonance imaging.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: Slowly progressive behavioral and personality changes following a seizure may be a manifestation of MOG-related disease in children.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
In this study, we present a transparent deep learning framework relying on 3D convolutional neural networks (CNNs) and layer-wise relevance propagation (LRP) for diagnosing multiple sclerosis (MS), the most widespread autoimmune neuroinflammatory disease. MS is commonly diagnosed utilizing a combination of clinical presentation and conventional magnetic resonance imaging (MRI), specifically the occurrence and presentation of white matter lesions in T2-weighted images. We hypothesized that using LRP in a naive predictive model would enable us to uncover relevant image features that a trained CNN uses for decision-making. Si...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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