Examining the validity of the Multiple-Sclerosis Walking Scale-12 with Rasch analysis: Results from an Italian study

Publication date: Available online 19 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): D Marengo, R Rosato, G Gamberini, P Cavalla, M Gironi, F Patti, L Prosperini, C SolaroAbstractBackgroundThe Multiple Sclerosis Walking Scale (MSWS-12) has showed good psychometric properties in reports exploring its validity using Classical Test Theory methods. Findings from recent studies using Item Response Theory methods advance the idea that some aspects of the MSWS-12 does not fully comply with some requirements of sound measurement.Research questionThe present study investigated whether the measurement properties of the Italian version of the MSWS-12 met the assumptions of the Rasch model.MethodsSample consisted of 199 patients with a diagnosis of MS (50% female; Mean age (SD) = 48.15 (12.33)). Analyses were performed using both unidimensional and multidimensional Rasch modeling techniques.ResultsRating scale for items assessing need for support when walking, and ability to run, showed significant functioning problems. A revision of the rating scale improved the measurement properties of these items. Items assessing need for support showed signs of multidimensionality and differential item functioning when controlling for patients’ disease course and EDSS score. Additionally, included items did not appear to cover the full range of impairment as observed in the sample.SignificanceEmerging findings are consistent with those from previous studies in hig...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: Available online 16 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Edgar Carnero C, Pablo A. López, Juan Pablo Pettinicchi, Ricardo Alonso, Santiago Tizio, Verónica Tkachuk, Alejandro Caride, Ian GaleaAbstractBackgroundDemographics, clinical and imaging prognostic factors have been reported in large series of people with multiple sclerosis (PwMS). However, personalized long-term prognosis (LTP) is varied and uncertain in each particular case. Currently, there is limited evidence on how PwMS feel about prognosis communication and their coping strategies. Therefore, we ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R. Cutter, Robert J. Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on health care utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexual ori...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We present the reader with a brief review on the AHCT procedure, its immunomodulatory mechanism of action in MS, the most recent evidence in support of its use in patients with relapsing-remitting multiple sclerosis (RRMS), as well as its cost considerations.Recent findingsThe first meta-analysis of clinical trials of AHCT for patients with MS demonstrated durable 5-year progression-free survival rates and low treatment-related mortality. Recently, the first randomized controlled phase III clinical trial demonstrated AHCT to be superior to best available therapy for a subset of patients with RRMS. This led to the American ...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
Conclusions: Persons with MS who use wheelchairs were interested in exercise, but need resources for engagement in regular exercise programs that yield meaningful health benefits. This study provided guidance for creating personalized, structured exercise programs for persons with MS who use wheelchairs that may improve overall wellness, independence, and quality of life. Implications for rehabilitation Exercise training programs often do not account for the unique needs and wants of persons with multiple sclerosis (MS) who use a wheelchair. Personalized, structured exercise programs for persons with MS who use wheelchairs...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
ConclusionFinger motor performance assessment provides important hints about upper limb disability, which should be evaluated in relation to age, disease duration and EDSS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile. NK cells are proposed to play an immunoregulatory role in MS, and expansion of the NKG2C(+) subset was recently associated with reduced disability progression. To further explore this issue, additional adaptive NK cell markers, i.e., downregulation of FcεRIγ chain (FcRγ) and PLZF transcription factor, as well as antibody-dependent NK cell activation were ass...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
PMID: 31613653 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R Cutter, Robert J Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on healthcare-related utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexua...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
In conclusion, SD is extremely common in pwMS from Argentina. The previously mentioned physical and neuropsychological factors have a negative impact on sexual function.
Source: Sexuality and Disability - Category: Disability Source Type: research
Objective To determine the prevalence of functional gastrointestinal disorders, the demographic and clinical characteristics associated with the presence of functional gastrointestinal disorders, and the effects of these disorders with health-related quality of life (HRQOL) in a large, diverse population of persons with MS. Methods In 2014, we surveyed participants in the North American Research Committee on Multiple Sclerosis registry regarding functional gastrointestinal disorders using the Rome III questionnaire. Participants also reported their sociodemographic characteristics, disability status using Patient Determin...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Gastrointestinal, Multiple sclerosis, All epidemiology Research Source Type: research
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