Emergence of blaVIM-2, blaNDM-1, blaIMP-7 and blaGES-1 in blaKPC-2 harbouring Pseudomonas aeruginosa isolates in Brazil
Publication date: Available online 19 September 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Alexsandra Maria Lima Scavuzzi, Elizabeth Maria Bispo Beltrão, Elza Ferreira Firmo, Érica Maria de Oliveira, Fernanda Gomes Beserra, Ana Catarina de Souza Lopes
ConclusionThe study highlights the importance of regular surveillance programs, an efficient infection control program, strict adherence to antiseptic measures and use of a rational antibiotic policy for the early diagnosis and better management of CRBSI.
ConclusionThe draft genome sequence reported here will lay the foundation for future research on antimicrobial resistance and pathogenic mechanisms in K. quasipneumoniae subsp. quasipneumoniae and also will promote comparative analysis with genomic features among different sources of clinically important multidrug-resistant strains.
ConclusionIt is concluded that NIT resistance in the studied NIT-RE. coli isolates was mainly mediated by nfsA and nfsB alterations.
ConclusionOur findings suggest that curcumin has potential as an anticlostridial agent. More work is needed to further investigate the efficacy of curcumin as a standalone drug or as a supplement of current drugs of choice, as it has no antagonistic activities but might overcome their drawbacks.
Authors: Bassetti M, Giacobbe DR, Peghin M, Irani P Abstract Introduction: Antimicrobial resistance poses a substantial threat to global public health concern, since it decreases the probability of effectively treating an infection and increases risk of morbidity and mortality. Areas covered: In this review, the authors discuss the advantages and disadvantages of classical and novel trial designs for evaluating novel antibiotics for infections due to multidrug-resistant organisms (MDRO). An inductive literature search was performed using different keywords pertinent to the reviewed topics. Expert opinion: The need ...
This study investigated the C. acnes inhibitory activity of Callicarpa americana leaves, a native Southeastern United States shrub historically used by Native Americans to treat fever, stomachache, and pruritis. Flash chromatography fractions of the ethyl acetate-soluble C. americana ethanol leaf extract (649C-F9 and 649C-F13) exhibited MICs ranging from 16 to 32 µg ml−1 and IC50 range of 4–32 μg ml−1 against a panel of 10 distinct C. acnes isolates. Cytotoxicity against an immortalized human keratinocyte cell line (HaCaTs) skin was detected at more than eight times the dose required for growth i...
ConclusionsCarbapenamase production along with intrinsic colistin resistance in infecting bacterial pathogens can cause fatal outcomes in the resource limited countries like Nepal where new antibiotic combinations ceftazidime+ Avibactam, or aztreonam +avibactam are not available. Drug resistance patterns including OXA 48 producer should be characterized in all cases by standard phenotypic methods or by Xpert Carba-R assay and larger studies are required to know the exact burden of OXA 48 producer in Nepal.
AbstractBackgroundBrucellosis is one of the most severe widespread zoonoses caused by the Gram-negative bacteriumBrucella species. The diagnosis and clinical assessment of human brucellosis are very important for the management of patients, while there is a lack of effective methods to detectBrucellae. Classical culture ofBrucella species is time consuming and often fails. A simple and sensitive assay is needed for diagnosis ofBrucella infection and monitoring of treatment in man.MethodsBlood samples and peripheral blood mononuclear cells (PBMCs) were collected from 154 patients hospitalized for brucellosis.Brucella antibo...
ConclusionThe AMK resistance rate in M. abscessus clinical isolates in this study was low (2.6%). The A1408 G mutation in rrs and overexpression of WhiB7 and Tap were the predominant mechanisms of AMK resistance in M. abscessus.
ConclusionIn summary, our results show that farms are an important reservoir of colistin-resistant E.coli, added to other additional genes, such as blaESBL. The transfer of manure from animals to soil and irrigation water might be spreading a mix of multiple resistances, posing a worrying threat to human health.Graphical abstract