Investigating Outcomes of Adolescents and Young Adults (10–24 Years of Age) Lost to Follow-up from Tuberculosis Treatment in Gaborone, Botswana

This retrospective study investigated outcomes among lost to follow-up (LTFU) adolescents and young adults (AYAs: 10–24 years of age) with tuberculosis (TB) registered from 2008 to 2014 in Gaborone, using surveillance data. Of 68 LTFU AYAs, 16 repeated treatment; 8 completed and 6 were again LTFU. Of 4 confirmed deaths, 3 had TB/HIV coinfection. Approaches to improve AYA retention in TB care are needed.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research

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DiscussionIntestinal TB most commonly affected region is the ileocaecal, accounts for 64% of the incidence of gastrointestinal TB. The main reasons for the predilection of ileocaecal region are due to relatively longer faecal static, the abundant of lymphoid tissue, a neutral pH environment and absorptive transport mechanisms that allow swallowed mycobacterium to be absorbed. Intestinal TB may pose similar symptoms as those found in pulmonary TB, yet patients most commonly presenting with abdominal pain. Bacteriological signs and histopathological findings are gold standard for ITB diagnosis. Therapy for ITB includes pharm...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
In this study, we attempted to identify the key structural feature for highly potent GyrB inhibitors through 2D-QSAR using HQSAR, 3D-QSAR using CoMSIA and molecular dynamics (MD) simulations approaches on a series of thiazole urea core derivatives. The best HQSAR and CoMSIA models based on IC50 and MIC displayed the structural basis required for good activity against both GyrB enzyme and mycobacterial cell. MD simulations and binding free energy analysis using MM-GBSA and waterswap calculations revealed that the urea core of inhibitors has the strongest interaction with Asp79 via hydrogen bond interactions. In addition, ca...
Source: SAR and QSAR in Environmental Research - Category: Environmental Health Authors: Tags: SAR QSAR Environ Res Source Type: research
Conclusions: A six-month course of isoniazid proved to be safe and effective in the treatment of LTBI, which is essential to reducing the risk of developing active tuberculosis.RESUMO Objetivo: Descrever a incid ência de tuberculose ativa e a ocorrência de eventos adversos do tratamento com isoniazida em pacientes diagnosticados com tuberculose latente (TBL), portadores de doenças inflamatórias crônicas e tratados com agentes imunobiológicos em uma área endêmica no Brasil. Métodos: O diagnóstico de TBL foi feito com base em anamnese, exame clínico, ra...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
To describe the surgical techniques in a case of female genital tuberculosis (TB) with superimposed tubo-ovarian abscess (TOA) in a developed country.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 1: Laparoscopy (10:00 AM — 10:10 AM) 10:00 AM: STATION P Source Type: research
Background: Previously, we have found that blockade of PD-1/PD-Ls pathway could enhance CD4+ T cells-mediated protective immunity in patients with active tuberculosis (ATB). However, the mechanism of PD-1/PD-Ls pathway involved in negative regulation of anti-TB immunity has been still unclear. Recently, the study of human immunodeficiency virus (HIV) infection demonstrated that PD-1 could induce the expression of basic leucine zipper ATF-like transcription factor (BATF) to inhibit CD8+ T cell function. While the mechanism of immune regulation of BATF in Mycobacterium tuberculosis (M. tb) infection has not yet been elucidat...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we evaluated the immunogenicity and efficacy of two attenuated vaccines, BCG and MTBVAC, after each was given to 17 goats (2  months old) and then exposed for 9 months to goats infected withM. caprae. In general, MTBVAC-vaccinated goats showed higher interferon-gamma release than BCG vaccinated goats in response to bovine protein purified derivative and ESAT-6/CFP-10 antigens and the response was significantly higher than that observed in the control group until challenge. All animals showed lesions consistent with TB at the end of the study. Goats that received either vaccine showed significantly ...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
[The Herald] Zimbabwe has paid US$300 000 to the Global Fund to fight Aids, Tuberculosis and Malaria in addition to another US$200 000 which was paid a fortnight ago for its 2017-2019 commitment.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[Cameroon Tribune] The event which was yesterday, October 10, 2019 presided over by the French President, Emmanuel Macron ended with donors attaining the 14 billion dollar target.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
ACS Chemical BiologyDOI: 10.1021/acschembio.8b00849
Source: ACS Chemical Biology - Category: Chemistry Authors: Source Type: research
S Turkucar, B Makay, H Tatari, E UnsalJournal of Postgraduate Medicine 2019 65(4):233-236 Pigmented villonodular synovitis (PVNS) is a rare benign disorder of a joint which affects its synovium, tendon sheaths and bursas. While most cases of PVNS are adult patients aged between 20-50 years, few afflicted children have also been reported. Clinical signs of PVNS are insidious and non-specific. Pain, swelling and stiffness are the major symptoms. Magnetic Resonance Imaging (MRI) is the best radiological method for diagnosis of PVNS, as the initial X-ray is normal in early phase of disease in most cases. Therefore, diagnosis ...
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
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