Use of Second-line Medications and Treatment Outcomes in Children With Tuberculosis in a Single Center From 2007 to 2018

Background: The incidence of drug-resistant forms of tuberculosis (DR-TB) and the number of children treated with second-line drugs (SLDs) are increasing. However, limited amount of information is available regarding the use of SLDs in this population. Methods: To describe the treatment of pediatric TB with SLDs and factors associated with use of SLDs in children with and without documented DR-TB, records of pediatric TB patients referred to a center in Italy from 2007 to 2018 were reviewed retrospectively. Results: Of 204 children diagnosed with active TB during the study period, 42 were treated with SLDs because of confirmed or probable drug resistance (42.8%), adverse reactions to first-line drugs (7.1%), central nervous system involvement (11.9%) or unconfirmed possible drug resistance (38.1%). There were no deaths or adverse reactions to SLDs reported. Treatment was successful in 85.2% children treated with first-line drugs and 92.9% children treated with SLDs. After adjusting for calendar period, the only factor associated with DR-TB was
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

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Tuberculosis (TB) remains a leading killer among infectious diseases of humans worldwide. Delayed diagnosis is a crucial problem in global TB control programs. Bacteriological methods currently used to diagnose TB in endemic countries take up to 8 weeks, which poses a significant delay in starting antibiotic therapy. The presence of a heterogeneous population of Mycobacterium tuberculosis, the causative agent of TB, is among the reasons for delayed diagnosis by bacteriological methods. Previously, it has been shown that mycobacterial resuscitation-promoting factors (RPFs), a family of proteins secreted by actively growing ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
[Global Fund] Lyon, France -At the opening of the Sixth Replenishment conference, the Global Fund announced a range of private sector partners that will spur innovation to accelerate the end to HIV, tuberculosis and malaria, the world's deadliest infectious diseases.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Global Fund] Geneva -Efforts to find and treat people with tuberculosis are showing remarkable progress, with 7 million people with TB found globally in 2018, including 600,000 more people than in 2017.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Condition:   Tuberculosis Interventions:   Device: DOT Selfie Intervention;   Other: In-person DOT Sponsors:   University of Georgia;   Makerere University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The Global Report includes trends in TB incidence and mortality, data on case detection and treatment results for TB, multidrug-resistant TB, TB/HIV, and TB prevention. The report also includes an overview of pipelines for new TB diagnostics, drugs and vaccines.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
[Daily Trust] The Federal Government has pledged $12 million to the Global Fund to tackle HIV, tuberculosis and malaria.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
Publication date: Available online 20 October 2019Source: Microchemical JournalAuthor(s): Archana Kushwaha, Neha Gupta, Juhi Srivastava, Ambareesh Kumar Singh, Meenakshi SinghAbstractHere, a selective sensing technology for the drug ethionamide used to treat multi-drug resistant tuberculosis is developed based on molecular imprinting. The molecular imprinting matrix is developed strategically by molecular modelling via density functional theory. 3-Thiophene acetic acid was predicted as suitable functional monomer for imprinting ethionamide. Polymeric film was formed on the surface of glassy carbon electrode by electropolym...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whetherMycobacterium tuberculosis (Mtb) directly regulates myeloid commitment. We demonstrated that exposure toMtb directs primary human CD34+ cells to differentiate into monocytes/macrophages. In vitro myeloid conversion did not require type I or type II IFN signaling. In contrast,Mtb enhanced IL-6 responses by CD34+ cell cultures and IL-6R neutralization inhibited myeloid differentiation and decreased mycobacterial growth in vitro. Integrated systems biology analysis of transcriptomic, proteomic and genomic data of large data sets...
Source: eLife - Category: Biomedical Science Tags: Computational and Systems Biology Immunology and Inflammation Source Type: research
Chronic obstructive pulmonary disease (COPD) and pulmonary tuberculosis (PTB) share a number of common risk factors, including innate immunity-related genetic factors. In the present study, we compared the rol...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
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