Dilated cardiomyopathy and rhabdomyolysis caused by hypopituitarism: a challenging diagnosis.

Dilated cardiomyopathy and rhabdomyolysis caused by hypopituitarism: a challenging diagnosis. Acta Cardiol. 2019 Sep 19;:1-5 Authors: Verhoestraete P, Marijn C, Jan D, Hans V PMID: 31536463 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research

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We present two young patients (
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
In this study, H9c2 cells a type of rat cardiac myoblasts, were used as model cardiac muscle cells. The use of a lipid composition used to prepare the β-MEND (where MEND denotes multifunctional envelope-type nano device) permitted the particles to be efficiently internalized by H9c2 cells, as evidenced by flow cytometry analyses. Intracellular observations by confocal laser scanning microscopy showed that the β-MEND efficiently accumulated in mitochondria of H9c2 cells. We also constructed an RP/β-MEND that contained a mitochondrial RNA aptamer to achieve mitochondrial delivery in H9c2 cells. The successful ...
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research
Conditions:   Inherited Cardiac Arrhythmias;   Long QT Syndrome;   Arrhythmogenic Right Ventricular Cardiomyopathy;   Brugada Syndrome;   Catecholaminergic Polymorphic Ventricular Tachycardia Intervention:   Sponsors:   University of British Columbia;   Kingston Health Sciences Centre;   Quebec Heart Institute;   Montreal Heart Institute Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The pathogenesis and cardiovascular impact of type 2 diabetes (T2D) may be different in South Asians compared with other ethnic groups. The phenotypic characterization of diabetic cardiomyopathy remains debate...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
ConclusionsThese models predict the risks of mortality and HF hospitalization in patients with HFpEF and emphasize the importance of health status data in determining prognosis. (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist [TOPCAT]; NCT00094302)Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: October 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 10, SupplementAuthor(s): C. Blakely, R. Hart, G. VanDam, L. Smith, M. Hazell, D. Campbell, P. Branscombe, H. Abdollah
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsWe describe a unique and novel cellular model that provides insight into the mitochondrial abnormalities present in DCMA and identifies SS-31 as a potential therapeutic for this devastating disease.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract Dilated cardiomyopathy (DCM) is a clinical syndrome characterized by left ventricular dilatation and contractile dysfunction. It is the most common cause of heart failure in young adults. The advent of next-generation sequencing has contributed to the discovery of a large amount of genomic data related to DCM. Mutations involving genes that encode cytoskeletal proteins, the sarcomere, and ion channels account for approximately 40% of cases previously classified as idiopathic DCM. In this scenario, geneticists and cardiovascular genetics specialists have begun to work together, building knowledge and establishing m...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Introduction The muscular dystrophies (MD) are a group of genetically heterogeneous muscle diseases marked by progressive wasting and weakness of the skeletal and cardiac muscles1. Duchenne muscular dystrophy (DMD) is the most common and most severe form. It is an X-linked disorder affecting 1 in 5000 live male births2,3. DMD is caused by mutations in the DMD gene, which encodes the muscle fiber membrane protein dystrophin. Deficiency or complete absence of dystrophin makes muscle fibers sensitive to damage upon contraction, leading to plasma membrane leakage and muscle fiber degeneration, which eventually leads to progres...
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research
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