Efficacy and Safety Curcuma zadoaria L. to inactivate the hydatid cyst protoscoleces.

Efficacy and Safety Curcuma zadoaria L. to inactivate the hydatid cyst protoscoleces. Curr Clin Pharmacol. 2019 Sep 18;: Authors: Mahmoudvand H, Pakravanan M, Kheirandish F, Jahanbakhsh S, Sepahvand M, Niazi M, Rouientan A, Aflatoonian MR Abstract Now, surgery is considered as the most reliable method for hydatid cyst treatment. Present protoscolicidal substances used in operating and percutaneous methods have restrictions because of the severe adverse effects for example biliary tract fibrosis, and liver necrosis. Thus, the present work aimed to evaluate the chemical composition of Curcuma zadoaria essential oil and investigate its efficacy and safety against hydatid cyst protoscoleces. Collected protoscoleces from liver fertile hydatid cysts of infected sheep were exposed to different concentrations of the essential oil (35-280 µl/mL) for 5-30 min in vitro and ex vivo. Then by using the eosin (0.1% eosin staining) exclusion assay the viability of protoscoleces was studied. In next step, 24 male NMRI mice were applied to assess the toxicity of C. zadoaria essential oil by measuring biochemical and hematological parameters. Based on the obtained results, C. zadoaria essential oil had a powerful protoscolicidal activity in vitro so that at the 300 and 150 µg/ml entirely eliminates the parasite after 5 and 10 minutes; whereas at lower doses demonstrated weak protoscolicidal activity. In ex vivo assay, no similar effect with in vitr...
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research