A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats.

A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats. Can J Physiol Pharmacol. 2019 Sep 19;: Authors: Gvozdjakova A, Kucharska J, Kura B, Vancova O, Rausova Z, Sumbalova Z, Ulicna O, Slezak J Abstract Mitochondria are the major source of cellular energy metabolism. In their function they produce a significant amount of free radicals, which in turn affects their function. Imbalance between ROS and antioxidant defense leads to oxidative stress. In this paper we demonstrate that the consumption of molecular hydrogen-rich water (HRW) resulted in stimulated rat cardiac mitochondrial electron respiratory chain function and increased levels of ATP production by Complex I and Complex II substrates. Similarly, coenzyme Q9 levels in rat plasma, myocardial tissue and mitochondria were increased and malondialdehyde levels in plasma were reduced after HRW administration. Based on obtained data we hypothesize a new metabolic pathway of the H2 effect in mitochondria on Q-cycle and in mitochondrial respiratory chain function. Q-cycle contains three coenzyme Q forms: coenzyme Q in oxidized form (ubiquinone), radical form (semiquinone) or reduced form (ubiquinol). H2 may be donor of both - electron and proton in the Q-cycle and thus we can suppose stimulation of coenzyme Q production. When ubiquinone is reduced to ubiquinol, lipid peroxidation is reduced. Increased CoQ9 concentration can stimulate electron ...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research