Liposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and Aversive Memories

This study investigated the effects of free morphine and morphine encapsulated in unilamellar and multilamellar liposomes on antinociception and on the expression and extinction of the positive and negative memories associated with environmental cues. The hot plate test was used to measure central pain. The rewarding effects of morphine were analyzed by the conditioned-place preference (CPP) test, and the aversive aspects of naloxone-precipitated morphine withdrawal were evaluated by the conditioned-place aversion (CPA) paradigm. Our results show that encapsulated morphine yields prolonged antinociceptive effects compared with the free form, and that CPP and CPA expression were similar in the free- or encapsulated-morphine groups. However, we demonstrate, for the first time, that morphine encapsulation reduces the duration of reward and aversive memories, suggesting that this technological process could transform morphine into a potentially less addictive drug. Morphine encapsulation in liposomes could represent a pharmacological approach for enhancing extinction, which might lead to effective clinical treatments in drug addiction with fewer side effects.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Authors: Sheldon RR, Weiss JB, Do WS, Forte DM, Carter PL, Eckert MJ, Sohn VY Abstract INTRODUCTION: Surgery is a known gateway to opioid use that may result in long-term morbidity. Given the paucity of evidence regarding the appropriate amount of postoperative opioid analgesia and variable prescribing education, we investigated prescribing habits before and after institution of a multimodal postoperative pain management protocol. MATERIALS AND METHODS: Laparoscopic appendectomies, laparoscopic cholecystectomies, inguinal hernia repairs, and umbilical hernia repairs performed at a tertiary military medical cent...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
This article provides a review of the preclinical and clinical pharmacology of lorcaserin, including its pharmacokinetic and safety profiles. Preclinical studies with lorcaserin initially focused on simple measures of food intake and body weight gain, but have now expanded to include studies on its effects on appetitive aspects of feeding behaviour and models of binge-eating. A significant number of studies have also shown that lorcaserin alters behaviours related to drug use and addiction, in rodents and non-human primates. Potential clinically-relevant effects of lorcaserin have also been reported in models of pain and s...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
TIME held its first TIME 100 Health Summit on Thursday aiming to define — and shape — the future of health care. The Summit, which is an offshoot of the magazine’s annual TIME 100 list of influential people, featured scientists, politicians and entertainers, such as former President Bill Clinton, former Vice President Al Gore, NIH Director Dr. Francis Collins, actress Selma Blair, NBA commissioner Adam Silver, comedian Tig Notaro and former Planned Parenthood President Dr. Leana Wen. The day included a range of interviews, panels and performances. Here are the biggest moments from the Summit. Former Vice ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Comedy HealthSummit19 onetime Source Type: news
Authors: Houchard G, Kullgren J, Saphire M, Porter K, Abel S Abstract Evidence guiding inpatient management of buprenorphine is lacking-this retrospective cohort study evaluated the clinical impact of hospital continuation versus discontinuation of buprenorphine at an academic medical center. The primary outcome was inpatient oral morphine equivalents (OME). Secondary outcomes included patient pain levels, functional assessment, and hospital length of stay. One hundred thirty-one patients (74 continued buprenorphine, 57 discontinued) were included in the analysis. Median OME were significantly lower among patients ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
University of Rochester Medical Center researchers have been selected as part of a national initiative by the National Institutes of Health to develop new non-addictive treatments for pain to improve patient care and curb the use and abuse of opioids.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
Crack addicts are turning YouTube chiropractors into huge viral stars
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Painkiller dea national take back day opioids prescription drug abuse prescription drug addiction prescription drug detox prescription drug use prescription drugs prescription medication prescri Source Type: blogs
In this study, the stereotyped behaviors and cognitive functions related to different types of tactile and auditory inputs were investigated in the rats following chronic exposure to the morphine, methadone, and buprenorphine. Here, three addicted groups received morphine, methadone, and buprenorphine while the control rats received saline for 21 days. Our results demonstrated that the opioid-treated groups showed stereotyped behaviors including grooming and rearing. In the behavioral level, prepulse inhibition and preference indices were not changed significantly in the opioids-treated groups compared to those of the sali...
Source: Physiology and Behavior - Category: Physiology Source Type: research
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Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Symptom Management and Supportive Care Cancer Care and the Opioid Crisis Source Type: research
When someone has an addiction to Vicodin and is ready to become sober, there are many questions that may arise. These can include: Where should I go for treatment? How much will it cost? How long will treatment take? What is Vicodin withdrawal like? Since there are many unknowns when it comes to getting treatment for addiction, it is very important to do research and find out as much as you can. This way, you will feel more prepared when you enter treatment and will be able to become much more comfortable throughout the process. This includes knowing what to expect when you are detoxing from Vicodin and what it might feel...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Substance Abuse anxiety in withdrawal detox opioid opioids vicodin withdrawal symptoms Source Type: blogs
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