Evaluation of haematopoietic stem cell transplantation in patients diagnosed with cutaneous T cell lymphoma at a tertiary care centre: Should we avoid chemotherapy in conditioning regimes?

Evaluation of haematopoietic stem cell transplantation in patients diagnosed with cutaneous T cell lymphoma at a tertiary care centre: Should we avoid chemotherapy in conditioning regimes? Br J Dermatol. 2019 Sep 19;: Authors: Ritchie S, Qureshi I, Molloy K, Yoo J, Shah F, Stevens A, Irwin C, Chaganti S, Scarisbrick JJ Abstract Advanced stage mycosis fungoides (MF) and Sézary syndrome (SS) account for ~30% of patients with cutaneous T-cell lymphomas (CTCL). The prognosis is poor with a median survival of 36 months.1 Treatments rarely result in durable remissions and recent management guidelines recommend allogeneic haematopoietic stem cell transplant (HSCT) for eligible patients as the best chance of improved survival. PMID: 31536644 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Conditions:   Peripheral T Cell Lymphoma;   Transformed Mycosis Fungoides Intervention:   Drug: AFM13 Sponsor:   Affimed GmbH Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Mycosis fungoides is the most common primary cutaneous T cell lymphoma, characterized by erythematous patches and plaque lesions with slow progression to cutaneous tumors or extracutaneous involvements in some patients. We aimed to evaluate the clinical characteristics, treatment responses, disease courses, and mortality rates of our MF cases. The data of 100 patients with MF were retrospectively examined from medical records in our clinic between January 2005 and January 2015. Demographic and clinical characteristics of the patients, disease stage, treatment protocols, response to treatment, recurrence, progression, and m...
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research
Conclusion: Doxycycline is not suitable as a sole agent in the treatment of early stages of classic MF, acting mainly by anti-inflammatory rather apoptotic function. PMID: 31526286 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Cutaneous T cell lymphomas (CTCLs) comprise a relatively rare group of non-Hodgkin lymphoma characterized by neoplastic infiltration of the skin [1]. Mycosis fungoides (MF) is the most common CTCL, accounting for nearly 55% of cases, whereas S ézary syndrome (SS) is less commonly seen [2]. Clinical presentation of CTCL is heterogeneous, and prognosis depends on the particular subtype and stage of diagnosis [3].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Revisiting the initial diagnosis and blood staging of Mycosis Fungoides and Sézary Syndrome with the KIR3DL2 marker. Br J Dermatol. 2019 Sep 05;: Authors: Roelens M, de Masson A, Ram-Wolff C, Maki G, Cayuela JM, Marie-Cardine A, Bensussan A, Toubert A, Bagot M, Moins-Teisserenc H Abstract BACKGROUND: The early diagnosis of Sézary syndrome is challenging. Loss of CD7 and CD26 expression on CD4 T cells is currently used criteria in the initial diagnosis and staging of Sézary patients. OBJECTIVES: Our goal was to evaluate the respective value of CD26, CD7 and KIR3DL2 expression ...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Cutaneous T-cell lymphomas (CTCLs) comprise a relatively rare group of non-Hodgkin lymphoma characterized by neoplastic infiltration of the skin [1]. Mycosis Fungoides (MF) is the most common CTCL accounting for nearly 55% of cases whereas S ézary syndrome (SS) is less commonly seen [2]. Clinical presentation of CTCL is heterogeneous and prognosis is dependent on the particular subtype and the stage of diagnosis [3].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Mycosis fungoides cutaneous-type T-cell lymphoma (MF-CTCL) is a rare non-Hodgkin lymphoma. In patients with early stage MF-CTCL, topical chlormethine (=mechlorethamine) 0.016% w/w gel (equivalent to 0.02% chlormethine HCl) was reported safe and effective, but usage may be limited due to the development of contact dermatitis. The primary endpoint of the current study was to determine if Triamcinolone significantly reduces the development of chlormethine-induced contact dermatitis using the newly formulated 0.016% w/w gel.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research
In vitro studies have indicated that staphylococcal enterotoxin-producing bacteria promote activation of STAT3 in malignant cutaneous lymphoma (Sezary syndrome) T cells. We investigated the skin microbiome of patch stage mycosis fungoides (MF) compared to normal skin by 16S amplicon sequencing and whole genome shotgun sequencing (WGS). Swab specimens were taken from MF patches and contralateral healthy appearing skin of 20 patients. The most common genera were Staphylococcus (30,0 %), Corynebacterium (22,3 %) Propionibacterium (5,0 %) and Streptococcus (3,0 %).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research
Clinical and laboratory diagnostics of mycosis fungoides (MF), the most common cutaneous lymphoma is challenging. Our previous work described 4 promising markers of S ézary syndrome (SS): T-plastin, Twist, NKp46 and KIR3DL2 (Michel et al. 2013). Tox has been shown to be an additional marker for MF and SS. The aim of the present study was to confirm this combination of blood-derived markers in a validation cohort of SS, erythodermic and earlier MF for improving d iagnosis and predicting prognosis. Patients with a confirmed diagnosis of MF or SS and patients with other skin diseases were included.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
In this report, we present a case of CD30+ transformed MF and discuss the clues that allow us to make the challenging distinction between transformed MF and other CD30+ CTCLs. We review histologic and clinical features of these different disorders, with a focus on the revised World Health Organization classification of primary cutaneous lymphomas.
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
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