Radiation Therapy for Pediatric Brain Tumors using Robotic Radiation Delivery System and Intensity Modulated Proton Therapy

This study recruited two centers with expertise in treating pediatric brain tumors with robotic radiation delivery system photon therapy and proton therapy, respectively, to study the plan quality and the dose deposition characteristics of robotic radiation delivery system photon and intensity modulated proton therapy (IMPT) plans.Methods and MaterialsA total of 18 patients clinically treated with robotic radiation delivery system were planned with intensity-modulated-proton-therapy (IMPT). Cases were planned per the standard of care of each institution but, respected the same planning objectives. The comparison was performed in three aspects: the plan quality, dose fall-off characteristics around target volume and the volume of high, intermediate, and low dose bath.ResultsAll robotic radiation delivery system and IMPT plans meet the planning objectives. However, IMPT significantly reduces the maximum dose of the OARs away from the planning target volume (PTV) such as cochlea and eye (P
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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What can radiation oncology residents expect to find in the job market upon...Read more on AuntMinnie.comRelated Reading: Proton therapy works well for pediatric brain tumors ASTRO: RT, surgery up stage IV lung cancer survival ASTRO: SABR is effective for oligometastatic cancers ASTRO: Weekly breast radiation therapy is safe ASTRO: AI's rad therapy future is in predicting outcomes
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Children with brain tumors had better neurocognitive outcomes with proton therapy treatment compared with X-ray radiation therapy, according to a new study.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
(Northwestern Memorial HealthCare) Proton therapy treatment for pediatric brain tumor patients is associated with better neurocognitive outcomes compared to x-ray radiation therapy according to a study by Northwestern Medicine.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
CONCLUSIONS: Brainstem injury is a rare complication of radiation therapy for both photons and protons. Substantial dosimetric data have been collected for brainstem injury after proton therapy, and established guidelines to allow for safe delivery of proton radiation have been defined. Increased capability exists to incorporate LET optimization; however, further research is needed to fully explore the capabilities of LET- and RBE-based planning. PMID: 29619963 [PubMed - in process]
Source: Health Physics - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Authors: Kortmann RD, Seidel C, Müller K, Hirsch FW Abstract Attainment of local control is a cornerstone in the management of brain tumors in children. Treatment of progressive low-grade and all high-grade gliomas traditionally includes resection followed by fractionated radiotherapy (FRT) or FRT alone in neoplasms not amenable to surgical removal. While in younger children chemotherapy is typically used as a first-line non-surgical management option, FRT in such patients remains the standard of salvage therapy. Recent improvements in techniques for radiation treatment planning and delivery allow conformal an...
Source: Progress in Neurological Surgery - Category: Neurosurgery Tags: Prog Neurol Surg Source Type: research
Limited clinical data in children treated with pencil beam scanning proton therapy for a brain tumor are available. We retrospectively analyzed our pediatric patients and reviewed magnetic resonance imaging changes after proton therapy, to assess the rate of radiation necrosis and white matter lesions. Overall, children treated with PBS proton therapy demonstrated a low prevalence of symptomatic radiation necrosis and white matter lesions, compared to similar cohorts treated with either proton or photon radiation therapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Proton therapy is increasingly used for treatment of primary brain tumors. Recent concern has emerged regarding potentially higher rates of pseudoprogression, the development of new enhancement within the radiation field, after proton therapy compared to photon therapy. Pseudoprogression can be difficult to distinguish from true progression and is poorly described for patients with oligodendroglioma. We retrospectively reviewed 68 patients with grade 2 or 3 oligodendroglioma treated with proton (n = 27) or photon (n = 41) therapy. All patients were treated between 2004 and 2015 and had a minimum of 6&nb...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: RADIATION THERAPY Source Type: research
Reduced doses for radiation therapy (RT) for pediatric medulloblastoma at the...Read more on AuntMinnie.comRelated Reading: Pediatric proton therapy treatments on the rise SNMMI: PET, MRI may predict pediatric brain tumor outcomes ASTRO: Study lauds proton therapy Imaging advances therapy assessment Proton therapy offers hope to pediatric brain cancer patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Reuters) – When Yves Jongen stood at the controls of his proton therapy machine 15 years ago to treat a cancer patient for the first time he was petrified. Now Jongen’s company IBA is hiring 400 engineers to cope with demand for the technology, increasing its workforce by a third, and expanding its production capacity to make up to 30 machines a year, from a maximum of 8 now. “It is such a responsibility to send a beam of potentially lethal particles into the body of a fellow human being. It is exciting but scary at the same time,” he said. Proton therapy made the front pages in Britain l...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Business/Financial News Radiosurgery IBA Source Type: news
Radiation therapy remains a highly effective therapy for many pediatric central nervous system tumors. With more children achieving long-term survival after treatment for brain tumors, late-effects of radiation have become an important concern. In response to this problem, treatment protocols for a variety of pediatric central nervous system tumors have evolved to reduce radiation fields and doses when possible. Recent advances in radiation technology such as image guidance and proton therapy have led to a new era of precision treatment with significantly less exposure to healthy tissues. These developments along with the ...
Source: Journal of Child Neurology - Category: Neurology Authors: Tags: Topical Review Articles Source Type: research
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