Intramyocardial bone marrow stem cells in patients undergoing cardiac surgical revascularization.

CONCLUSIONS: In this phase 1 trial, direct intramyocardial injection of autologous BMSCs in conjunction with TMR or CABG was technically feasible and could be performed safely. Preliminary results demonstrate improved cardiac function and quality of life in patients at one year after treatment. PMID: 31526779 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

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AbstractAimsPeripartum cardiomyopathy (PPCM) is a heart disease affecting women during the last month of pregnancy or in the first months after delivery. The impact of the disease on mental health is largely unknown.Methods and resultsMajor mental disorders were assessed by a structured clinical interview in 40 patients with a confirmed PPCM diagnosis, and the data were compared with published prevalence in postpartum women. Circulating biomarkers associated with mental health, such as kynurenine, serotonin, and microRNA (miR) ‐30e, were evaluated in PPCM and compared with matched healthy pregnancy‐matched postpartum c...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Short Communication Source Type: research
This ECG was texted to me with no other information:Computer Diagnosis:SINUS TACHYCARDIAINCOMPLETE RIGHT BUNDLE BRANCH BLOCK [90+ ms QRS DURATION,TERMINAL R IN V1/V2, 40+ ms S IN I/aVL/V4/V5/V6]LEFT ANTERIOR FASCICULAR BLOCK [QRS AXIS
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
This is a re-posting of a Tweet by Robert Jones (@RJonesSonoEM), reproduced with permission, written by Pendell MeyersA middle aged female with history of smoking presented to the ED with " bad heartburn. "Here is her prior baseline ECG (first), and her ED ECG (second):Baseline:ED ECG:What do you think? Do you agree with the computer's interpretation of " Normal ECG " ?This was posted on Twitter and Dr. Smith (and several others) replied that it shows OMI. Dr. Smith said " No " (meaning " No, I do not agree with the computer " ). " New ST elevation in V4-V6. New distortion of S ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
DiscussionThus, no further ECGs were recorded and there was no angiogram or stress test or CT coronary angiogram.  Acute MI does not often present with syncope alone, without any other symptom, so the pretest probability of acute MI is low.However, the troponins are high and, in my opinion, the data above does not rule out the possibility of type 1 MI.  There were very elevated troponins without a significant known stress (which might cause a type 2 MI).  The troponins are NOT consistent with STEMI (OMI), which typically has a troponin I of at least 5 ng/mL.  Nevertheless, I don't think a thrombosis rel...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
A middle-aged man complained of 15 minutes of classic angina that resolved upon arrival to the ED.Here is his initial ECG:What do you think?There is sinus rhythm with RBBB and possible LPFB (see Dr. Grauer's detail below).  There is ST elevation in II, III, and aVF, and reciprocal ST depression in aVL.  And there are Q-waves in both inferior and lateral leads.  So this is indeed diagnostic of myocardial infarction.Should we activate the cath lab?No! Not immediately, at least, because this is NOT diagnostic of ACUTE (occlusion) myocardial infarction (Acute OMI).  We need to do some more investigatio...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
ConclusionsIn this phase 1 trial, direct intramyocardial injection of autologous BMSCs in conjunction with TMR or CABG was technically feasible and could be performed safely. Preliminary results demonstrate improved cardiac function and quality of life in patients at one year after treatment.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractIschemic heart disease and non-ischemic dilated cardiomyopathy are the most common causes of arrhythmic sudden cardiac death (SCD). Implantable cardioverter defibrillator (ICD) therapy is the only strategy that proved to be effective in preventing SCD in high-risk individuals while the role of antiarrhythmic drugs is limited to symptoms relief. Current guidelines recommend selecting candidates to ICD implantation based on etiology, symptoms of heart failure (NYHA class), and severely depressed left ventricular ejection fraction, but these parameters are neither sensitive nor specific. The review addresses the mecha...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
We examined the modifying effects of social support on depressive symptoms and health-related quality of life (QoL) in patients receiving coping skills training (CST). Method: We considered the modifying effects of social support in the Coping Effectively with Heart Failure clinical trial, which randomized 179 heart failure (HF) patients to either 4 months of CST or usual care enhanced by HF education (HFE). CST involved training in specific coping techniques, whereas HFE involved education about HF self-management. Social support was assessed by the Enhancing Recovery in Coronary Heart Disease (ENRICHD) Social Support Inv...
Source: Health Psychology - Category: Psychiatry & Psychology Source Type: research
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the heart...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults. Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/ Cells are equipped with a protein disposal system in the form of the proteaso...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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