Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance

In conclusion, long-term noradrenergic denervation reduces the number of dopaminergic neurons in the substantia nigra and affects the functionality of the nigrostriatal system. Thus, locus coeruleus is important for maintenance of nigral dopaminergic neurons.
Source: Neurochemistry International - Category: Neuroscience Source Type: research