p300 mediates the histone acetylation of ORMDL3 to affect airway inflammation and remodeling in asthma.

CONCLUSION: p300-mediated HAT modulates the expression of the asthma susceptibility gene ORMDL3, thereby improving the process of airway inflammation and remodeling in asthma.
PMID: 31536903 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - September 15, 2019 Category: Allergy & Immunology Authors: Cheng Q, Shang Y, Huang W, Zhang Q, Li X, Zhou Q Tags: Int Immunopharmacol Source Type: research