Role of preoperative pregabalin in reducing inhalational anaesthetic requirements in abdominal hysterectomy: randomized controlled trial.

In this study, we hypothesized that preoperative pregabalin reduces inhaled isoflurane requirements. METHODS: We have investigated the effectiveness of preoperative oral pregabalin 150 mg in women undergoing elective open total abdominal hysterectomy under general anesthesia. A prospective, randomized, double-blind, controlled study was conducted in a university hospital. The study included 50 women (18-60 yrs.), ASA I or II, admitted for abdominal hysterectomy under general anesthesia. Exclusion criteria were allergy to pregabalin; calcium channel blockers, antiepileptic drugs, antidepressant drugs, any analgesics, sedatives, or oral hypoglycemic agents. Patients were randomized into 2 groups; Pregabalin group received oral pregabalin 150 mg &placebo group. Main outcome measures was inhaled isoflurane requirements to maintain hemodynamics ± 20% of baseline &bispectral index of 40 - 60, measured using MAQUET Flow-I anesthetic machine. Secondary outcomes were attenuation of pressor response to intubation, postoperative pain, and first time for rescue analgesia, total analgesics and adverse effects. RESULTS: Isoflurane consumption was significantly less in pregabalin group (7.80 ± 1.27ml h -1) versus (12.27 ± 2.49 ml h-1) in the control group, (P= 0.00). Better hemodynamic stability was in pregabalin group. First postoperative hour: the mean VAS score was significantly higher in control group (7.10 ± 1.20) compared to pregabalin group...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Related Links:

CONCLUSIONS: we found an association between SIBO and allergic disease, especially allergic rhinitis, cow's milk protein allergy and asthma. Thus, SIBO should be ruled out in pediatric patients with CAP and allergic disease. PMID: 31617366 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
By Sandee LaMotte, CNN (CNN) — Toxic heavy metals damaging to your baby’s brain development are likely in the baby food you are feeding your infant, according to a new investigation published Thursday. Tests of 168 baby foods from major manufacturers in the US found 95% contained lead, 73% contained arsenic, 75% contained cadmium and 32% contained mercury. One fourth of the foods contained all four heavy metals. One in five baby foods tested had over 10 times the 1-ppb limit of lead endorsed by public health advocates, although experts agree that no level of lead is safe. The results mimicked a previous&nb...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Consumer Featured Health News Syndicated CBSN Boston CNN Source Type: news
ConclusionPreprocedure gabapentin significantly reduces immediate and delayed postprocedural patient discomfort following PNN cryoablation.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study is designed to clarify the incidence of epidural morphine induced pruritus (EMIP) in Chinese Han and Tibetan parturients after cesarean section (CS) and to identify the correlated risk factors. This is a prospective multicenter observational study. Follow-up evaluations were performed at 3 hours, 6 hours, 12 hours, 24 hours, and 48 hours after morphine administration. The primary outcome was EMIP incidence. Other details were also recorded for risk factor screening. Totally 284 parturients receiving CS were enrolled and 247 completed the study. The overall incidence of EMIP was 18.6% (46 in 247). The...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Abstract The purpose of this study was to describe the therapeutic effectiveness/pain relief of moderate-dose lidocaine infusions in patients with chronic neuropathic pain. Retrospective reviews of medical records were conducted for 40 patients referred to a midwestern pain clinic for management of intractable neuropathic pain despite use of multiple medications and treatment modalities. Descriptive statistics were used to summarize patients' demographic data, lidocaine dosing and infusion rate, daily opioid intake, adjuvant medication use, and medication allergies and intolerances. Paired samples t test was used ...
Source: AANA Journal - Category: Anesthesiology Authors: Tags: AANA J Source Type: research
You're reading The Mind and Body Connection; How Posture Affects Your Mood, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. We all have heard the phrase, Mind, Body, and Soul, but very few people understand how they all work together. Most people believe the phrase "I can achieve anything I put my mind to". In some cases this is true, however, when it comes to physical well-being and posture, the body plays a huge role in how we feel. The body sends messages known as "somatic markers" through neurotra...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement confidence posture Source Type: blogs
You're reading How You Can Help Yourself Get A Good Night’s Sleep, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Sleep is an essential part of our lives and it’s important that our bodys get enough sleep on a regular basis. Without this we can struggle to function correctly and be more prone to picking up infections, as our body becomes run down. If you struggle to get to sleep, there are ways in which you can improve your environment in order to achieve a better night’s rest. We all know that we s...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
Abstract Eosinophilic gastrointestinal disorder (EGID) is an uncommon disease that is accompanied by intestinal eosinophil infiltration without a secondary cause of eosinophilia. Eosinophilic enteritis is a secondary portion of EGID that can present a range of gastrointestinal symptoms according to the affected depth of the intestinal layer. The subserosal type of eosinophilic enteritis presenting as ascites is relatively rarer than the mucosal type. In general, eosinophilic enteritis occurs in patients with food allergies, but its mechanism is unclear. The authors experienced a 29-year-old female patient with a l...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
Discussion Pulmonary embolism (PE) is potentially life-threatening but fortunately rare event especially in the pediatric population. It was first described in children in 1861. PE is likely underreported because of minimal or non-specific clinical symptoms. The incidence is estimated at 0.05-4.2% with the 4.2% based on autopsy reports. It is probably also increasing as more central venous catheters (CVC) are used, and more children are surviving previously poor prognostic diseases. There is a bimodal distribution with cases
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
In this study we aimed to elicit the impact of different palliative therapy options on survival in a nationally representative sample of sinonasal cancer patients.MethodsNational Cancer Database 2004 ‐2015 data sets were queried for cases of primary sinonasal cancer (N = 380). Kaplan‐Meier analysis was utilized to determine median overall survival (M‐OS) and overall survival (OS) among the different treatment cohorts (pain management, palliative radiation therapy, palliative chemotherapy, palliative surgery, and combination therapy). Prognostic factors were elicited by comparing OS by log‐rank tests and subsequent ...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
More News: Allergy | Allergy & Immunology | Anesthesia | Anesthesiology | Calcium | Hysterectomy | Lyrica | Pain | Study | Women