biomarkers for predicting future exacerbations in adult patients with asthma.

[BIOMARKERS FOR PREDICTING FUTURE EXACERBATIONS IN ADULT PATIENTS WITH ASTHMA]. Arerugi. 2019;68(8):942-947 Authors: Hirai K, Shirai T, Itoh K PMID: 31534105 [PubMed - in process]
Source: Allergology International - Category: Allergy & Immunology Tags: Arerugi Source Type: research

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We report a rare case of vascular ring with Kommerell diverticulum leading to a misdiagnosis of asthma in a 39 ‐year‐old woman. Anomalies of the aortic arch associated with Kommerell diverticulum (KD) are rare congenital malformations. Symptomatic thoracic vascular rings presenting in adults are rare. We report a case of a 39 ‐year‐old woman who was diagnosed with uncontrolled asthma. She was complaining of worsening respiratory symptoms with dysphagia. Imaging studies and preoperative findings concluded to type II congenital anomaly of the aortic arch or Neuhauser's anomaly: a right‐sided aortic arch with aberra...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Condition:   Asthma Intervention:   Other: Questionnaire Sponsor:   University Hospital, Lille Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Asthma Intervention:   Drug: DUPIXENT® Sponsors:   Regeneron Pharmaceuticals;   Sanofi Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Yilmaz I, Türk M, Nazik Bahçecioğlu S, Tutar N, Gülmez I Abstract BACKGROUND: Oral corticosteroid (OCS) dependent severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps (SEA-CRSwNP) would be a suitable phenotype for mepolizumab treatment. OBJECTIVE: To evaluate the short-term efficacy of mepolizumab treatment on the OCS dependant SEA-CRSwNP Methods: Baseline and 24th-week results [daily OCS doses, asthma exacerbation frequency, asthma control test(ACT) scores, blood eosinophil levels, FEV1 values and numerical analog scale (NAS) of CRSwNP symptoms] of the patients th...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
CONCLUSIONS: In adults with severe chronic rhinosinusitis and nasal polyps, using regular topical nasal steroids, dupilumab improves disease-specific HRQL compared to placebo, and reduces the extent of the disease as measured on a CT scan. It probably also improves symptoms and generic HRQL and there is no evidence of an increased risk of serious adverse events. It may reduce the need for further surgery. There may be little or no difference in the risk of nasopharyngitis. In similar patients, mepolizumab may improve both disease-specific and generic HRQL. It is uncertain whether it reduces the need for...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Introduction Asthma is a heterogeneous condition, characterised by chronic inflammation of the airways, typically managed with inhaled bronchodilators and corticosteroids. In the case of uncontrolled asthma, oral corticosteroids (OCSs) are often prescribed. Good adherence and inhalation technique are associated with improved outcomes; however, it is difficult to monitor appropriate drug intake and effectiveness in individual patients. Exhaled breath contains thousands of volatile organic compounds (VOCs) that reflect changes in the body's chemistry and may be useful for monitoring drug pharmacokinetics/pharmacodynamics. We...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
In the study presented in this issue of the European Respiratory Journal, Brinkman et al. [1] investigated the link between traces of asthma medication in urine of severe asthmatic patients and exhaled volatile organic compounds (VOCs). One potential application of this study in clinical practice would be an easy, indirect measurement of compliance using detection of exhaled breath biomarkers resulting from metabolism and excretion of medications by the lungs.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
Nurhayat Yakut, Eda Kepenekli Kadayifci, Ela Erdem Eralp, Yasemin GokdemirLung India 2020 37(2):161-163 Allergic bronchopulmonary aspergillosis (ABPA) is recognized as a rare, progressive, allergic disorder in patients with cystic fibrosis (CF) and asthma. Treatment of ABPA mainly includes systemic corticosteroids (CSs) and antifungal agents. Here, we report posaconazole treatment in a 9-year-old male child with ABPA and also review the literature on antifungal management of ABPA. The child with CF was admitted to the emergency room with complaints of fever, productive cough, and acute dyspnea. Auscultation of the lungs r...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Sujeet Rajan, Nithya J Gogtay, Mahanjit Konwar, Urmila Mukund ThatteLung India 2020 37(2):169-173 The Global Initiative for Asthma (GINA) recently released their updated Global Strategy for Asthma Management and Prevention Guide (2019). The pocket guide for practicing clinicians states that “the 2019 GINA strategy report represents the most important change in asthma management in 30 years.” An important recommendation is the change in treatment strategy for the management of mild asthma where the guideline recommends that” all adults and adolescents with asthma should receive either symptom driven (in m...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
(Trinity College Dublin) Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease, and which may offer a promising target for drug designers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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