Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats

ConclusionOur results demonstrate electrophysiological evidence for AF promoting effects of RAP in rats and several molecular similarities between the effects of RAP in large and small mammalian models.
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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We report that Tbx5 and Gata4 interact with opposite signs for atrial rhythm controls compared with cardiac development. Using mouse genetics, we found that AF pathophysiology caused by Tbx5 haploinsufficiency, including atrial arrhythmia susceptibility, prolonged action potential duration, and ectopic cardiomyocyte depolarizations, were all rescued by Gata4 haploinsufficiency. In contrast, Nkx2-5 haploinsufficiency showed no combinatorial effect. The molecular basis of the TBX5/GATA4 interaction included normalization of intra-cardiomyocyte calcium flux and expression of calcium channel genes Atp2a2 and Ryr2. Furthermore,...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
This study examined plasma concentrations of lower than recommended dosing of apixaban in older adults with non-valvular AF.Journal of the American Geriatrics Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news
This study sought to evaluate the effectiveness of PAP therapy for SDB on AF recurrence.Methods:This was a single-center, retrospective study conducted at a tertiary referral center. All adult patients who had SDB on polysomnography and underwent AF intervention (ablation or cardioversion) following polysomnography from January 1992-December 2014 were analyzed. Primary outcome was time to first-documented recurrence of AF after AF intervention by Kaplan–Meier estimates.Results:Among 30,188 patients with obstructive and central SDB, 429 had this diagnosis before AF intervention; 269 were“PAP-adherent users,&rdqu...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
The most common causes of chronic liver disease in the developed world —nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) — are the hepatic manifestations of an insulin-resistant state that is linked to visceral adiposity and systemic inflammation. NAFLD and NASH lead to an expansion of epicardial adipose tissue and the release of pro inflammatory adipocytokines that cause microcirculatory dysfunction and fibrosis of the adjoining myocardium, resulting in atrial fibrillation as well as heart failure with a preserved ejection fraction (HFpEF).
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Review Source Type: research
Acute superior mesenteric artery thrombosis is usually fatal; however, early intravascular treatment using a mechanical thrombectomy device can be an effective intervention. A 70-year-old man with atrial fibrillation presented with sudden abdominal pain; superior mesenteric artery thrombosis was confirmed using contrast-enhanced computed tomography. Thrombolysis, mechanical fragmentation, aspiration, and thrombectomy were successfully performed using the Trevo ® XP ProVue stent retriever via a brachial approach, and intestinal necrosis was avoided.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
Atrial fibrillation (AF) is the most common type of arrhythmia. Abnormal atrial myocyte Ca2+ handling promotes aberrant membrane excitability and remodeling important for atrial arrhythmogenesis. The sequence of molecular events leading to loss of normal atrial myocyte Ca2+ homeostasis is not established. Late Na+ current (INa,L) is increased in atrial myocytes from AF patients together with an increase in activity of Ca2+/calmodulin-dependent kinase II (CaMKII).
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
ConclusionThe likelihood of AF detection by an ILR in the first month post-CS is low. Thus, the diagnostic yield of 30  days of AECG monitoring is likely to be limited. These data suggest a rationale for proceeding directly to ILR implantation prior to hospital discharge in CS patients, as many have AF detected during longer follow-up.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
Authors: Bashir MU, Bhagra A, Kapa S, McLeod CJ Abstract Atrial fibrillation is the most common symptomatic arrhythmia that is associated with stroke. Contemporary management of the disease is focused on anticoagulation to prevent stroke, coupled with catheter ablation to limit symptoms and prevent deleterious cardiac remodeling. Emerging data highlights the importance of lifestyle modification by managing sleep apnea, increasing physical activity, and weight loss. There is significant data that supports a link between the autonomic nervous system, arrhythmia development, and atrial fibrillation therapy. It is like...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
This study aimed to report the procedural data and initial results of a combined ablation technique using AI ‐guided high‐power (AI‐HP; 50 W) ablation for PVI.MethodsSymptomatic AF patients were consecutively enrolled and underwent wide ‐area contiguous circumferential PVI. Contact‐force catheters were used, ablation power was set to 50 W targeting AI values (550 anterior and 400 posterior). Esophageal temperature was monitored during procedure, all patients underwent postablation esophageal endoscopy.ResultsPVI was achieved in all (n  = 50, mean age: 68 ± 9 years,...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Journal of Cardiovascular Electrophysiology, EarlyView.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: EDITORIAL –INVITED Source Type: research
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