Drugs Used in the Treatment of Bipolar Disorder and their Effects on Cholesterol Biosynthesis- A Possible Therapeutic Mechanism.

Conclusions: These data suggest that BD drug combination is increasing cholesterol biosynthesis and the newly synthesised cholesterol is being utilised within the cells, possibly for synthesis of new membranes to facilitate neurite outgrowth. This mechanism possibly underpins clinical efficacy in individuals with BD treated with polypharmacy.
PMID: 31535581 [PubMed - as supplied by publisher]

Source: The World Journal of Biological Psychiatry - September 18, 2019 Category: Psychiatry Authors: Kidnapillai S, Bortolasci CC, Panizzutti B, Spolding B, Connor T, Bonifacio K, Sanigorski A, Dean OM, Crowley T, Jamain S, Gray L, Leboyer M, Berk M, Walder K Tags: World J Biol Psychiatry Source Type: research