Senegal: Senegal to Offer Free Breast and Cervical Cancer Treatment

[allAfrica] Johannesburg -The government of Senegal will begin to offer free breast or cervical cancer chemotherapy in public hospitals from October 2019, reports the BBC.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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A mucoadhesive nanogel is introduced to prolong the residence time and dramatically improve the drug efficiency in local cervical cancer therapy. This nanogel not only displays mucoadhesive properties that adhere strongly to mucins but also contributes to the penetration of drugs in epithelial cell monolayers. The new design with multivalent interactions exerts excellent anticancer activity in cervical cancer. AbstractCervical cancer treatment is subject to limited drug access to locally diseased targets and generally resistant to chemotherapy, thus it is essential to develop a local drug delivery system to overcome these ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
ConclusionNeoadjuvant chemotherapy followed by laparoscopic and open radical hysterectomy seems to be a safe treatment option for locally advanced cervical cancer, in terms of similar survival outcomes and morbidity of treatment with CCRT. However, the present study is too limited to permit conclusions due to its small sample size and retrospective design despite statistical methods for adjusting confounding factors.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionPlatinum-based NACT was well tolerated in patients with LACC and showed moderate response activity. Compared to NCIV, NCIA showed an evident advantage in the clinical response with a similar toxicity rate. The clinical efficacy of NCIA deserves further evaluation.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
This study aimed to compare the survival outcomes of NACT followed by laparoscopic or open radical hysterectomy versus CCRT in patients with locally advanced cervical cancer.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 4: Oncology (1:40 PM — 1:50 PM) 1:40 PM STATION D Source Type: research
The aim of this study was to evaluate the safety and efficacy of intra-arterial (NCIA) versus intravenous (NCIV) neoadjuvant chemotherapy in managing patients with locally advanced cervical cancer (LACC).
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 4: Oncology (1:30 PM — 1:40 PM) 1:30 PM STATION S Source Type: research
AbstractResistance to chemotherapy is widely recognized as one of the major factors limiting therapeutic efficacy and influences clinical outcomes in patients with cancer. Many studies on various tumor types have focused on combining standard-of-care chemotherapy with immunotherapy. However, for cervical cancer, the role of neoadjuvant chemotherapy (NACT) on the local immune microenvironment is largely unexplored. We performed a pilot study on 13 primary cervical tumor samples, before and after NACT, to phenotype and enumerate tumor-infiltrating T-cell subpopulations using multiplex immunohistochemistry (CD3, CD8, FoxP3, K...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Peng-Hui Wang Radical hysterectomy (RH) is the standard treatment for early stage cervical cancer, but the surgical approach for locally bulky-size cervical cancer (LBS-CC) is still unclear. We retrospectively compared the outcomes of women with LBS-CC treated with neoadjuvant chemotherapy (NACT) and subsequent RH between the robotic (R-RH) and abdominal approaches (A-RH). Between 2012 and 2014, 39 women with LBS-CC FIGO (International Federation of Gynecology and Obstetrics) stage IB2–IIB were treated with NACT-R-RH (n = 18) or NACT-A-RH (n = 21). Surgical parameters and prognosis were compared. Patient ch...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Abstract INTRODUCTION: There is currently no standard of care for women with cervical cancer stage IB2 (FIGO 2018, ≥2 cm and
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
Abstract The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme method is used in Japan, most drug dosages, including cisplatin, are adjusted according to the estimated Ccr using the Jaffe method-based Scr level. The purpose of this study was to investigate whether assessment of re...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
ConclusionAlthough LM arising from gynecological cancers is considered rare, identification of LM may be important to predict prognosis and develop new therapeutic strategies.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
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