Knocking down SMC1A inhibits growth and leads to G2/M arrest in human glioma cells.

In this study, we investigated the role of SMC1A in human glioma. We found that SMC1A was expressed at abnormally high levels in human glioma tissue and in cultured U251 glioma cells. Knocking down SMC1A expression in U251 cells with SMC1A-targeted interfering RNAs inhibited cell growth and induced G2/M cell cycle arrest. Furthermore, expression of the cell cycle associated gene CCNB1IP1 was dramatically increased, whereas expression of Cyclin B1 was decreased in SMC1A-deficienct U251 cells. These results suggest that SMC1A upregulation is involved in the pathogenesis of glioma. PMID: 23638217 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/23638217?dopt=Abstract

Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Ma Z, Lin M, Li K, Fu Y, Liu X, Yang D, Zhao Y, Zheng J, Sun B Tags: Int J Clin Exp Pathol Source Type: research