Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases.

This report describes the immunohistochemical study of four ACCs of the oral cavity. The male to female ratio was 1:3. The age was 43, 51, 59 and 64 years. The location was tongue (n=2), buccal mucosa (n=1), and gingiva (n=1). Histochemically, all ACCs were positive for neutral, carboxylated and sulfated mucins. Immunohistochemically, ACC was consistently positive for cytokeratin (CK) AE1/3, CK 34βE12, CK5/6, CK7, CK14, CK18, p63, CA19-9, c-KIT (CD117), PDGFRA, MUC1, and Ki-67 (labeling index: 5%, 15%, 20% and 40%). ACC was consistently negative for CK8, CK20, desmin, S100 protein, CD34, chromogranin, MUC2, MUC5AC and MUC6. Some ACCs were positive for CK CAM5.2 (3/4), CK19 (1/4), EMA (2/4), CEA (2/4), vimentin (3/4), α-smooth muscle actin (2/4), p53 (2/4), CD10 (2/4), and synaptophysin (1/4). These results may provide basic knowledge of ACC of the oral cavity. PMID: 23638226 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research