Stem cell secretome as a new booster for regenerative medicine.

Stem cell secretome as a new booster for regenerative medicine. Biosci Trends. 2019;13(4):299-307 Authors: Xia J, Minamino S, Kuwabara K, Arai S Abstract Stem cells are an undifferentiated cell population that has the ability to develop into many different cell types and also has the ability to repair damaged tissues in some cases. For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relate to a paracrine modulatory effect rather than the replacement of affected cells at the site of injury. This paracrine modulatory effect derives from secretome which comprises a diverse host of growth factors, cytokines, chemokines, angiogenic factors, and exosomes which are extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells and are from about 30 to several hundred nanometers in diameter. The role of these factors is being increasingly recognized as key to the regulation of many physiological processes including leading endogenous and progenitor cells to sites of injury as well as mediating apoptosis, proliferation, migration, and angiogenesis. In reality, the immunomodulatory and paracrine role of these factors may mainly account for the therapeutic effects of stem cells...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research

Related Links:

ConclusionT1D prevalence is constantly increasing worldwide, but at slower pace in Africa in comparison to developed countries. Difficulties to access to high standard care and population poverty in Sub-Saharan Africa, represents a major independent factor of poor therapeutic observance.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
ConclusionGlenoid bone loss between 17% and 25% is considered to be a “subcritical bone loss” in our series, especially in male patients who are involved in sports or high-level activities.Level of evidenceIII, retrospective study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
ConclusionAs expected, the postoperative hip function is similar, but patients’ preference is not. The latter result might be true or possibly influenced by preoperative psychological factors and mental health. The DAA and the posterolateral or direct lateral approaches have shown to lead to a similar hip function, but a majority of patients subjectively prefer the DAA.Level of evidenceIII.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
In conclusion, Chinese postmenopausal women with T2DM had a similar risk of incident VFs, but a significantly higher risk of incident non-VF, compared to women without DM. Higher BMI did not modify the effect of T2DM on risk of VFs, but it increased the association be tween T2DM and risk of non-VFs. LS BMDT-score was similarly and negatively associated with VF risk in T2DM and non-DM women and appear to be useful for clinical evaluation of VF risk.
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
ConclusionTo optimize targeting and visualization of the surgical field in right pelvic sidewall/paracolic gutter, robotic arms can be placed in a straight line from above the pubic symphysis extending to the left subcostal line and between the midline vertical and midclavicular lines. Robotic tumor debulking should be considered in selected patients with recurrent ovarian cancer who present with oligo-metastatic disease, in the absence of carcinomatosis.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionThe survival outcome of laparoscopic radical hysterectomy is comparable to open radical hysterectomy after completing learning curve and reducing intraperitoneal tumor exposure during surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: November–December 2019Source: Journal of Minimally Invasive Gynecology, Volume 26, Issue 7, SupplementAuthor(s): KW Fan, MK Shu, A Eddib, C TysonStudy ObjectiveTo compare perioperative outcomes of patients undergoing standard oncology staging versus combined oncology staging and urogynecologic procedures for pelvic floor dysfunction repair.DesignA retrospective cohort study of two gynecologic oncology patients groups who underwent robotic assisted surgical staging versus surgical staging with concomitant pelvic floor repair.SettingMany women diagnosed with a gynecologic malignancy may have comorbid ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionRobotic isthmocele repair is a feasible technique when correctly chosen. Due to the raising number of cesarean sections, gynecologists will face this problem more frequently and must be aware of its indications as well as different approaches.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionThe robotic-assisted laparoscopy view, with the 3-D dimension, and the forceps joint make the suture easily to be performed by the gynecologic surgeon.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionThere are numerous reports of the minimally invasive repair of CSD; however, it remains unknown in the obstetrical literature when interventions are required. Patients with minimal myometrial thinning and without evidence of serosal dehiscence may not require repair of the defect. More evidence is needed to observe obstetrical outcomes with or without repair.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
More News: Alopecia | Biomedical Science | Brain | Diabetes | Diabetes Type 1 | Endocrinology | Gastroschisis Repair | Nanotechnology | Neurology | Orthopaedics | Osteoarthritis | Stem Cell Therapy | Stem Cells | Transplants