A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia.

A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia. Neurochem Res. 2019 Sep 16;: Authors: Wang L, Zhang Y, Wang C, Zhang X, Wang Z, Liang X, Alachkar A, Civelli O Abstract Dehydrocorybulbine (DHCB), an alkaloid from Corydalis yanhusuo. W.T, has been identified as a dopamine receptor antagonist. We extended our assessment of its pharmacological profile and found that DHCB exhibits high to moderate binding affinities to sigma 1 and 2 receptors, serotonin 5-HT7 receptor, and histamine H2 receptors. This led us to evaluate DHCB properties in pharmacological (apomorphine and MK-801) animal models of schizophrenia in mice. The pharmacological profile of DHCB was screened through radioligand receptor binding assays. Single dose of DHCB reversed the locomotor hyperactivity, stereotypy, and prepulse inhibition deficits induced by the dopaminergic agonist apomorphine. DHCB also reversed the depressive-like behavior and memory deficit induced by the glutamatergic antagonist MK-801 in the forced swim and the novel object recognition assays, respectively. These results indicate that DHCB effectively improves schizophrenia-like behavioral deficits that are induced by the disruption of dopaminergic and glutamatergic systems. The effectiveness of DHCB in reversing responses that mimic negative and cognitive deficits of schizophrenia might suggest that its anti-schizophrenia eff...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir J Source Type: research
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Source: Twin Research and Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Twin Res Hum Genet Source Type: research
Authors: Youssef P, Nath S, Chaimowitz GA, Prat SS Abstract This review aims to consolidate the available information on use of electroretinography as a diagnostic tool in psychiatry. The electroretinogram (ERG) has been found to have diagnostic utility in cocaine withdrawal (reduced light-adapted b-wave response), major depressive disorder (reduced contrast gain in pattern ERG), and schizophrenia (reduced a- and b-wave amplitudes). This review examines these findings as well as the applicability of ERG to substance use disorder, Alzheimer's disease, autism spectrum disorder, panic disorder, eating disorders, atten...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
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Source: European Psychiatry - Category: Psychiatry Source Type: research
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Source: International Journal of Law and Psychiatry - Category: Medical Law Authors: Tags: Int J Law Psychiatry Source Type: research
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Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
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Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
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