How bacteria can block xenophagy: an insight from Salmonella.

How bacteria can block xenophagy: an insight from Salmonella.
Autophagy. 2019 Sep 18;:1-2
Authors: Wen X, Klionsky DJ
Abstract
Xenophagy, a unique type of selective macroautophagy/autophagy, targets invading pathogens as part of the host immune response. In order to survive within the host, bacteria have established various self-defense mechanisms. In a recent paper from Feng Shao's lab, the Salmonella effector protein SopF has been demonstrated to block xenophagy by interrupting the vacuolar type H+-translocating (v-) ATPase-ATG16L1 axis, which is important for antibacterial autophagy initiation. SopF can specifically ADP-ribosylate Gln124 on ATP6V0C, a v-ATPase component, thus influencing recruitment of ATG16L1 onto the bacteria-containing vacuole within the host cytosol. Abbreviations: ATG: autophagy-related; S. Typhimurium: Salmonella enterica serovar Typhimurium; T3SS: type III secretion system.
PMID: 31530078 [PubMed - as supplied by publisher]

Source: Autophagy - September 17, 2019 Category: Cytology Authors: Wen X, Klionsky DJ Tags: Autophagy Source Type: research