Surgery alone for papillary thyroid microcarcinoma is less costly and more effective than long term active surveillance

This study aims to analyze complication rates of thyroid surgery, papillary thyroid microcarcinoma recurrence, and survival rates. Additionally, the costs of surgery versus hypothetic active surveillance for papillary thyroid microcarcinoma are compared in an Australian cohort.
Source: Surgery - Category: Surgery Authors: Source Type: research

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ConclusionThe results of our series of 13 cases indicate that intraoral soft tissue metastatic carcinomas have a male predilection with a male to female ratio of 11:2, are commonly found in the gingiva and alveolar mucosa (76.9%), present frequently as an easy-bleeding pyogenic granuloma-like lesion (92.3%). In addition, the most common primary cancer site is the liver.
Source: Journal of Dental Sciences - Category: Dentistry Source Type: research
Authors: Schroader B, Kong SX, Anderson S, Williamson T, Sireci A, Shields K Abstract INTRODUCTION: The development of precision medicine and targeted therapies have revolutionized cancer treatment. Historically, treatment was chosen based on the tumor-histology, but can now be tailored to patient-specific actionable biomarkers. Investigations have shown up to 40% of cancer patients who undergo molecular testing have an actionable biomarker with a drug currently available, and that patients benefit from these drugs. In 2018, larotrectinib became the first drug developed and approved exclusively as a tumor-agnostic ...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Conclusion: Patients chronically treated with lithium need to be screened for hypothyroidism, goiter, and hyperparathyroidism, as the prevalence of these endocrine abnormalities is higher in lithium-treated patients than in the general population. The growth inhibitory effects of lithium in medullary TC, pheochromocytoma/paraganglioma and carcinoid were achieved with supratherapeutic concentrations of lithium thus limiting its translational perspective. Currently available clinical data on the efficacy of lithium in the therapy of endocrine tumors in human is limited and associated with conflicting results.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Patients aged ≥55 years with stage T1-2N1M1 DTC according to the eighth edition AJCC/TNM cancer staging system should be downstaged and those with stage T4bN1M0 upstaged accordingly.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Kamińska-Winciorek G, Cybulska-Stopa B, Lugowska I, Ziobro M, Rutkowski P Abstract The introduction of immunotherapy into the treatment of cancer patients has revolutionised the oncological approach and significantly improved patient survival. The key drugs are immune checkpoint inhibitors (CPIs), whose mechanism of action is to elicit immune response against cancer cell antigens. Three types of CPIs are currently used and approved: an anti-CTLA-4 antibody, ipilimumab; anti-PD-1 antibodies, nivolumab and pembrolizumab; and anti-PD-L1 antibodies: atezolizumab, avelumab and durvalumab. CPIs have been widely...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
In Reply In our study, we reported that the incidence rate of pediatric thyroid cancer increased more rapidly during 2006 to 2013 than during 1973 to 2006. We proposed that this is likely owing to a combination of enhanced detection and a concurrent true increase in pediatric thyroid cancer incidence based on increased incidences of large tumors and regionally advanced disease. We have read the comments of Murakami et al and wish to address their concerns regarding the interpretation of the later finding.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
To the Editor We read with interest the article by Qian et al, who reported thyroid cancer incidence among children in the United States. On the basis of similar trends between tumor sizes (0.1-2.0 and>2 cm) and between extent of diseases (localized and regional), they suggested 2 causes of the increase: overdiagnosis, associated with a 2006 recommendation for a similar diagnostic and therapeutic approach in children as in adults by the American Thyroid Association; and environmental risk factors, such as increased exposure to medical radiation. The increase in large-tumor (>2 cm) thyroid cancer is not evidence of a ...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
The relationship between breast cancer (BC) and thyroid disease (TD) is still controversial. The aim of the study was to investigate the possible coexistence of TD in patients with newly diagnosed BC and its c...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research Source Type: research
We report the first case of a patient with colon cancer who was diagnosed with a thyroid metastasis in a noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). A 55-year-old male patient presented with a 19  mm thyroid nodule in the inferior left lobe. It was EU-TIRADS 5 on echography and suspicious of papillary thyroid carcinoma (Bethesda V) on cytology. Macroscopically, the nodule was fleshy and completely encapsulated. At frozen section examination, it demonstrated follicular architecture with mild atypia. Inside the nodule was a focus of tumor with glandular architecture, marked cell...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
Conditions:   Papillary Thyroid Cancer;   Papillary Thyroid Microcarcinoma Intervention:   Device: RFA Sponsor:   Mayo Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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