First molecular characterization of Leishmania infantum species in patients infected with visceral leishmaniasis in Misiones province, Argentina

Conclusion: This finding constitutes the first molecular identification of the Leishmania infantum species in autochthonous patients of Misiones province, Argentina. This study highlights the importance of PCR for species identification in epidemiological studies of visceral leishmaniosis in Argentina. PMID: 31529825 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research

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This study showed a high failure rate for HECT-CL thermotherapy in this setting. Leishmania tropica is known to be less sensitive to antileishmanial drugs, more temperature-resistant, and spontaneous healing is slower than that in L. major. More research is needed to identify low-cost, effective, and more patient-friendly treatment for L. tropica. PMID: 31595864 [PubMed - as supplied by publisher]
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Tags: Am J Trop Med Hyg Source Type: research
The Leishmania spp. protozoa are sandfly-borne intracellular parasites that are responsible for the leishmaniases, a complex of diseases with important clinical implication.1 In humans, the major clinical forms are cutaneous, mucocutaneous and visceral leishmaniasis, the latter being fatal if untreated. Most leishmanial infections remain asymptomatic in immunocompetent individuals; for example, the ratio of subclinical to clinical cases of Leishmania infantum infection has been reported to be around 50:1 in Spain.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Conclusion: This was the first molecular study of dog leishmaniasis from Saudi Arabia of dogs confirmed to have cutaneous leishmaniasis. Further epidemiological and molecular investigations of domestic and wild canine infections with L. major, L. tropica and L. infantum in endemic and nonendemic areas of Saudi Arabia are required, for leishmaniasis control. PMID: 31543911 [PubMed]
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
CONCLUSIONS: The presence of the Lutzomyia species that have been identified as vectors for Leishmania inside and around houses in the village of El Bledo, in El Carmen de Bolívar represents a risk of infection. Furthermore, the presence of Lu. panamensis is reported for first time in El Carmen de Bolívar in Colombia. Although the lack of detection of Leishmania spp. in D. marsupialis samples may suggest that D. marsupialis does not play an important role in the transmission cycle of Leishmania in this region, it is necessary to carry out further longitudinal studies to confirm this hypothesis. PMID: 3152...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
In conclusion,L.infantum-derived LPG was recognized by antibodies elicited during CanL in different infection stages and was shown to be a suitable antigen for specific clinical settings of veterinary diagnosis and for public health usage.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
CONCLUSION: In cases of VL suspicion and when the parasite is not observed in the bone marrow aspiration, the proposed model could be useful in discriminating between patients with and without VL, allowing to take a therapeutic decision while awaiting the definitive diagnosis. PMID: 31466803 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
This study aimed to identify sand fly fauna in an endemic area for VL to detect the prevalence ofL.infantum infection in theLu.longipalpis population and to elucidate the influence of bioclimatic factors on the monthly fluctuations of this vector. HP light traps were monthly set in the intradomicile and peridomicile of residences located in the central and beachfront areas of Cama çari, a VL endemic area. The sand fly collection was conducted in two periods: i) period 1—between December 2011 and November 2012 and ii) period 2—August 2014 and July 2015. Sand fly species were identified and detection ofL.i...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
The objective was to evaluate the potential of Fluorescence in Situ Hybridization as a diagnostic method for Cutaneous leishmaniasis in Sri Lanka. Literature on current laboratory tests used to diagnose Cutaneous leishmaniasis in Sri Lanka and globally was reviewed. Sri Lankan data were reviewed systematically following the PRISMA guidelines. A narrative of the results is presented. There is currently no gold standard diagnostic method for Cutaneous leishmaniasis. Fluorescence in Situ Hybridization has been previously applied to detect dermal pathologies including those involving infectious agents, and its use to detect th...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
Publication date: Available online 15 August 2019Source: Veterinary ParasitologyAuthor(s): Ana Vitória Verde Oliveira Rocha, Brenda Fernanda Sodré Moreno, Aline Diniz Cabral, Nayara Mendes Louzeiro, Leandro Macedo Miranda, Vivian Magalhães Brandão dos Santos, Francisco Borges Costa, Rita de Maria Seabra Nogueira, Arlei Marcili, Márcia Aparecida Sperança, Andréa Pereira da CostaAbstractVisceral leishmaniasis is a zoonotic disease caused by Leishmania infantum for which dogs are the main reservoir. In South America, presence of this disease is expanding along with increasing d...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Abstract Cutaneous leishmaniasis due to Leishmania tropica is increasingly documented in Europe and the Middle East. Besides its specific vector, Phlebotomus sergenti, permissive Phlebotomus sand flies are suspected as potential vectors of L. tropica. We investigated the susceptibility of two widely distributed species, Phlebotomus perniciosus and Phlebotomus tobbi. Laboratory-reared sand flies were infected experimentally with L. tropica strains differing in lipophosphoglycan epitopes, geographical distribution and epidemiology. High infection rates, heavy parasite loads and fully developed late-stage infections ...
Source: International Journal for Parasitology - Category: Parasitology Authors: Tags: Int J Parasitol Source Type: research
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