The protective effect of endothelin receptor antagonists against surgically induced impairment of gastrointestinal motility in rats.

This study indicates that delay in the intestinal transit in late phase of surgically induced POI involves an ET-dependent mechanism. PMID: 31527357 [PubMed - in process]
Source: Journal of Smooth Muscle Research - Category: Research Tags: J Smooth Muscle Res Source Type: research

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CONCLUSIONS: After elective midline laparotomy for colorectal resection, continuous wound infusion of a local anaesthetic compared to a normal saline placebo reduces postoperative pain at rest and the length of hospital stay, on the basis of high-certainty evidence. This means we are very confident that the effect estimates for these outcomes lie close to the true effects. There is moderate-certainty evidence to indicate that the intervention probably reduces opioid consumption via PCA and the time to first bowel movement. This means we are moderately confident that effect estimates for these outcomes are likely to be clos...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Publication date: Available online 11 October 2019Source: Trends in Anaesthesia and Critical CareAuthor(s): George ChapmanAbstract“Don’t worry, it’s more dangerous driving here than having the anaesthetic”. This statement may be reassuring, but it isn’t true. Despite its falsehood, it is often quoted as it evokes a visceral response that suggests the procedure is low risk.Communicating risks and probabilities to our patients is an everyday occurrence for clinicians - but are we correctly understood? Are we over-reliant on numerical expressions of risk? Could comparative examples of probabiliti...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
ConclusionSub-cutaneous and/ or intra-peritoneal anesthesia were not effective in reducing post-operative pain.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 11 October 2019Source: Trends in Anaesthesia and Critical CareAuthor(s): George ChapmanAbstract“Don't worry, it's more dangerous driving here than having the anaesthetic”. This statement may be reassuring, but it isn't true. Despite its falsehood, it is often quoted as it evokes a visceral response that suggests the procedure is low risk.Communicating risks and probabilities to our patients is an everyday occurrence for clinicians - but are we correctly understood? Are we over-reliant on numerical expressions of risk? Could comparative examples of probabilities aid the underst...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Postpartum hemorrhage is a leading cause of maternal and fetal mortality. Although rare, peripartum splenic rupture (PSR) is a lethal cause of bleeding due to variable presentation and delayed diagnosis. A 22-year-old gravida 2, para 0, abortus 1 (G2P0A1) woman presented for premature rupture of membranes and was diagnosed with Influenza A and chorioamnionitis. She underwent emergent cesarean delivery under general anesthesia. Postoperatively, her condition worsened despite treatment for presumed sepsis. She was taken to the operating room for an exploratory laparotomy, and a splenectomy was performed for splenic rupture. ...
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
CONCLUSIONS: Administration of midazolam as premedication for laparotomy patients did not improve the quality of recovery up to one week after surgery. General prescription of midazolam as premedication can be questioned and might only suit some patients. TRIAL REGISTRATION: www.clinicaltrials.gov (NCT01993459); registered 29 October, 2013. PMID: 31576513 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - Category: Anesthesiology Authors: Tags: Can J Anaesth Source Type: research
Publication date: Available online 24 September 2019Source: Saudi Journal of Biological SciencesAuthor(s): Qinghong Song, Yan ZhangAbstractIn order to study the construction of digital three-dimensional model of rabbit vascular network and provide a powerful basis for the model construction and image processing of human vascular network, in this study, rabbit abdominal and pelvic vessels are perfused with latex-bismuth oxide contrast agent. After that, the internal fibrous structure of the abdominal and pelvic vascular network in rabbits is studied by micro-computed tomography (Micro-CT). Angiography and post-processing so...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
CONCLUSION: A delayed consultation is not associated with a worse outcome. Complications should be ruled out by endoscopy. After a normal control, the patient can be discharged prematurely without further imaging. PMID: 31559621 [PubMed - as supplied by publisher]
Source: Zentralblatt fur Chirurgie - Category: Surgery Authors: Tags: Zentralbl Chir Source Type: research
ConclusionIntroduction of a dedicated geriatric surgical liaison service is associated with increased compliance with NELA standards. Despite more emergency laparotomies being performed on older patients, this was associated with improved mortality and rates of home discharge, consistent with published data. Targeted investment in surgical liaison services may therefore be warranted.
Source: Age and Ageing - Category: Geriatrics Source Type: research
This study aims to investigate the possible nephroprotective effect of lycopene on renal ischemic–reperfusion injury in mice model. Forty Swiss Albino adult male mice were randomly allocated onto one of the four study groups: sham group: mice had median laparotomy under anesthesia with no procedures performed, renal tissues and blood samples were collected. ischemic–reperfusion group (I–R-control): mice underwent median laparotomy under anesthesia, followed by 30 min bilateral renal ischemia. Renal tissues and blood samples were co llected after 2 h from reperfusion. Vehicle-treated group: mice ...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
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