Efficacy of immunosuppressants with bridge vasodilator therapy in severe lupus erythematosus ‐associated pulmonary arterial hypertension

AbstractOptimal management ofsystemic lupus erythematosus (SLE) ‐associated pulmonary arterial hypertension (PAH) remains unclear. Our observation describes the case of a 31‐year‐old SLE patient presenting with cardiogenic shock revealing severe PAH, in which a therapeutic scheme combining immunosuppressants (pulse cyclophosphamide and corticosteroids) and PAH‐specific drugs (bosentan, tadalafil, and epoprostenol) led to a complete normalization of pulmonary haemodynamics and allowed a progressive weaning of PAH vasodilators. This case report supports the efficacy of immunosuppressants and use of PAH‐specific therapy as a bridge therapy in severe SLE‐PAH. Further studies on larger population are required to confirm these findings.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research

Related Links:

Conclusions: It appears that further studies are necessary to explain this problem, perhaps to include an evaluation of TF levels in psoriatic skin. PMID: 31616219 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
In this study, we aimed to explore the efficacy and safety profile of apatinib monotherapy, or combined with chemotherapy or endothelial growth factor receptor (EGFR)-TKI in heavily pretreated non-small cell lung cancer (NSCLC) patients with brain metastases. We performed a retrospective analysis for relapsed NSCLC patients with brain metastases from our institute, whom received apatinib (250mg or 500mg p.o. qd) monotherapy, or combination with EGFR-TKI or chemotherapy as second- or more line systemic therapy until disease progression or unacceptable toxicity occurred. The objective response rate (ORR), disease control rat...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
Abstract Heart failure with reduced ejection fraction (HFrEF) is a progressive clinical syndrome commonly associated with left ventricle dilatation and characterized by reduced cardiac output, secondary pulmonary and systemic venous congestion, and inadequate peripheral oxygen delivery. It is common yet complex and requires synthesis of evidence-based guidelines along with strong clinical acumen. The following is a review of an illustrative case that highlights the important clinical considerations in diagnosis, assessment, and management of HFrEF commonly encountered in practice. Explanations provided highlight o...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Abstract The cumulative incidence of systolic heart failure is similar in men and women. However, major prognostic differences exist between genders. We sought to measure gender differences in furosemide prescribing patterns for patients with preexisting heart failure with reduced ejection fraction (HFrEF) admitted with Stage C acute decompensation, regardless of the underlying cause. We conducted a single-center retrospective analysis of patients admitted between 2015 and 2018 for acute on chronic decompensated HFrEF. Primary outcomes were differences in initial furosemide dose, total dose over the first 24&thins...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Authors: Gąsiorek P, Sakowicz A, Banach M, von Haehling S, Bielecka-Dabrowa A Abstract Purpose: The study is aimed at identifying echocardiographic and circulating biomarkers as well as hemodynamic indices of embolic stroke of undetermined etiology (ESUS) in patients aged
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Conditions:   Congenital Heart Disease;   Pulmonary Arterial Hypertension Intervention:   Other: Blood test Sponsor:   University Medical Center Groningen Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Arterial Hypertension Interventions:   Other: dual combination;   Other: triple combination;   Other: Standard of care Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Fund for Scientific Research Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Heart Failure,Congestive;   Drug Use;   Patient Care Intervention:   Behavioral: Educational outreach visit Sponsor:   Region Skane Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study implemented congestive heart failure self-management education in primary care using a holistic multidisciplinary approach with SMA to provide evidence-based interventions to improve depression, QOL, and health promotion outcomes. Patients participating in the holistic multidisciplinary SMA experienced improvement in depression, QOL, and health promotion behaviors. A comparison of the means between preintervention and postintervention showed an overall reduction in systolic blood pressure, weight, depression scores, QOL scores, and several indicators of health promotion lifestyle.
Source: Holistic Nursing Practice - Category: Nursing Tags: FEATURES Source Type: research
Authors: Yan D, Liu J, Zhang Y, Yuan W, Xu Y, Shi J, Li C, Wang Y, Peng L, Yang Y, Zhou J, Wu D, Liu Z, Zeng X, Zhang F, Zheng W, Zhao Y Abstract To investigate the clinical features of parenchymal neuro-Behcet's disease (p-NBD), we retrospectively reviewed the medical records of 1009 BD patients admitted to Peking Union Medical College Hospital from 2000 to 2016. Forty-two patients (25 males and 17 females) with p-NBD and eighty-four age- and sex-matched BD patients without neurological involvement who were served as controls were enrolled. Neurological onset was concomitant with the onset of BD in six cases (14.3...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
More News: Cardiogenic Shock | Cardiology | Cialis | Corticosteroid Therapy | Heart | Heart Failure | Hypertension | Lupus | Study