Acquisition of class C β-lactamase PAC-1 by ST664 strains of Pseudomonas aeruginosa.

Acquisition of class C β-lactamase PAC-1 by ST664 strains of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 Sep 16;: Authors: Bour M, Fournier D, Jové T, Pouzol A, Miltgen G, Janvier F, Jeannot K, Plésiat P Abstract Four ST664 (serotype O:5) strains of Pseudomonas aeruginosa highly resistant to antibiotics including ceftolozane/tazobactam and ceftazidime/avibactam but susceptible to colistin, were found to harbor the rare class C β-lactamase PAC-1 encoding gene on a chromosomally-located Tn1721-like transposon. Gene bla PAC-1 was associated with the 16S rRNA methylase determinant rmtF2, that confers pan-aminoglycoside resistance. These genotypically-related strains were isolated in repatriated patients from Mauricius and Afghanistan and close to a lineage reported in Nepal, Pakistan and India. PMID: 31527025 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research