Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification.

Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification.
Phys Med Biol. 2019 Sep 16;:
Authors: Horst F, Adi W, Arico G, Brinkmann KT, Durante M, Reidel CA, Rovituso M, Weber U, Zaunick HG, Zink K, Schuy C
Abstract
Measured cross sections for the production of the PET isotopes C-10, C-11 and O-15 from carbon and oxygen targets induced by protons (40-220 MeV) and carbon ions (65-430 MeV/u) are presented. These data were obtained via activation measurements of irradiated graphite and beryllium oxide targets using a set of three scintillators coupled by a coincidence logic. The measured cross sections are relevant for the PET particle range verification method where accurate predictions of the β+ emitter distribution produced by therapeutic beams in the patient tissue are required. The presented dataset is useful for validation and optimization of the nuclear reaction models within Monte Carlo transport codes. For protons the agreement of a radiation transport calculation using the measured cross sections with a thick target PET measurement is demonstrated.
PMID: 31530751 [PubMed - as supplied by publisher]

Source: Physics in Medicine and Biology - September 15, 2019 Category: Physics Authors: Horst F, Adi W, Arico G, Brinkmann KT, Durante M, Reidel CA, Rovituso M, Weber U, Zaunick HG, Zink K, Schuy C Tags: Phys Med Biol Source Type: research