Fast automated multi-criteria planning for HDR brachytherapy explored for prostate cancer.

Fast automated multi-criteria planning for HDR brachytherapy explored for prostate cancer. Phys Med Biol. 2019 Sep 16;: Authors: Breedveld S, Bennan ABA, Aluwini S, Schaart DR, Kolkman-Deurloo IK, Heijmen BJM Abstract We developed a fast and fully-automated, multi-criteria treatment planning workflow for high dose rate brachytherapy (HDR-BT). In this workflow, the patient-CT with catheter reconstructions and dwell positions are imported from the clinical TPS into a novel system for automated dwell time optimisation. The optimised dwell times are then imported into the clinical TPS. The aims of automation were 1) planner-independent, enhanced plan quality, 2) short optimisation times. Our in-house developed system for fully automated, multi-criteria external beam radiotherapy (EBRT) treatment planning (Erasmus-iCycle) was adapted for optimisation of HDR-BT dose distributions. The investigations were performed with planning CT scans with catheter reconstructions and delineations of twenty-five low- and intermediate-risk prostate cancer patients who were previously treated in our center with 4 x 9.5 Gy HDR-BT. Automatically generated plans (autoplans) were compared to the corresponding clinical plans. All evaluations were performed in the clinical TPS. The requested 95% tumour coverage was obtained for all autoplans, while this was only observed in 23/25 clinical plans. All autoplans showed a consistent reduction of the D1% for the high...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research