Investigating the Source of a Disease Outbreak Based on Risk Estimation: A Simulation Study Comparing Risk Estimates Obtained From Logistic and Poisson Regression Applied to a Dichotomous Outcome.
Conclusion: Poisson regression with robust standard errors proved to be a decisive and consistent method to estimate risk associated with a single source in an outbreak when the cohort data collection design was used. PMID: 31528132 [PubMed]
Conclusions: Norovirus is a major pathogen causing diarrhea in Shanghainese children. GII.Pe/GII.4-Sydney/2012 strains remained the predominant genotype. The emergence of GII.P17/GII.17 and GII.P16/GII.2 strains in sporadic diarrhea was consistent with norovirus-associated outbreaks attributable to these 2 novel variants in China. Continuous monitoring norovirus genotypes circulating in pediatric population is needed for current vaccine development.
Background: Influenza virus is one of the most common respiratory pathogens for all age groups and may cause seasonal outbreaks. Our aim was to identify risk groups and factors associated with severe clinical course including mortality in children with influenza-related lower respiratory tract infection (LRTI). Methods: We conducted a retrospective study in children hospitalized with influenza virus LRTI from 2008 to 2018. Data on demographic features, influenza type, viral coinfection, primary and secondary bacterial infections (SBIs), time of onset of antiviral treatment, comorbidities, hospitalization length, pedia...
Bacillus cereus isolates causing an outbreak in the neonatal intensive care unit were investigated using whole-genome sequencing. The outbreak coincided with construction work performed adjacent to the neonatal intensive care unit and ceased after strict sealing of the construction area. We found the outbreak to be polyclonal, however, the clonality did not correlate with the virulence in vivo. Genotypically similar isolates were associated with both lethal/severe infection and colonization/environmental contamination. Environmental bacterial load may be a major determinant of infection, especially in high-risk patients. C...
Conclusions: This study showed that EV-positivity rate for our SARI series was 9%. The molecular detection and characterization of EVs allowed for the rapid detection of an EV-D68 outbreak and revealed the presence of emerging EV types that may pose a public health threat. The lack of routine screening and EV characterization in respiratory tract infections hampers the assessment of their epidemiologic and molecular features.
The infectious risk of ERCP has historically been ascribed to biliary stasis and obstructive physiology from stones, strictures, or stents. Recent outbreaks, many of them from multidrug-resistant organisms (MDROs), have been attributed to the infectious carriage of the duodenoscope itself: so-called exogenous infection. This has drawn considerable attention and research efforts intended to better characterize the contributory risk of each of the following factors: instrument design, reprocessing measures (eg, manual and automated cleaning), surveillance strategies for detecting instrument contamination, and other quality metrics.
We present a novel kinetic Monte Carlo technique to study the susceptible-infected-removed model in order to simulate epidemic outbreaks on two quasiperiodic lattices, namely, Penrose and Ammann-Beenker. Our analysis around criticality is performed by investigating the order parameter, which is defined as the probability of growing a spanning cluster formed by removed sites, evolving from an initial system configuration with a single random chosen infective site. This system is studied by means of the cluster size distribution, obtained by the Newman-Ziff algorithm. Additionally, we obtained the mean cluster size, and a cu...
The Ebola outbreak in the eastern Democratic Republic of the Congo (DRC) officially remains a Public Health Emergency of International Concern, experts meeting in Geneva said on Friday.
Ebola is infecting and killing people in a gold mining area of eastern Democratic Republic of Congo, and the "complex and dangerous" outbreak still constitutes an international emergency, the World Health Organization (WHO) said on Friday.
UN says deadly Ebola outbreak in Congo still qualifies as global emergency
The most recent measles outbreak, which was the worst in the U.S. since 1992, may be over, but the impact of the disease is not.WebMD Health News