Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice.
CONCLUSION: Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. PMID: 31528245 [PubMed]
EchoSens creates non-invasive liver diagnosis medical devices. The company’s line of products, called FibroScan, work by measuring the speed of ultrasound waves as they move through liver tissue. This measurement can tell us about the state of ...
nia Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide. Notwithstanding the known susceptibility factors for NAFLD, i.e., obesity and metabolic syndrome, the exact cause(s) of this disease and the underlying mechanisms of its initiation and progression are not fully elucidated. NAFLD is a multi-faceted disease with metabolic, genetic, epigenetic, and environmental determinants. Accumulating evidence shows that exposure to environmental toxicants contributes to the development of NAFLD by promo...
Conclusion: The presence of the PNPLA3 G allele is associated with a risk of NAFLD. Our study shows that subjects with variant PNPLA3 are not only at increased risk for the development and progression of NAFLD, but also have increased insulin resistance. PMID: 31304703 [PubMed - in process]
The recent epidemic of chronic liver disease is related to the burden of non-alcoholic fatty liver disease (NAFLD), paralleling the worldwide increase of obesity.1 NAFLD is a complex condition related to metabolic derangements in insulin resistance (IR), but in a subset of patients the liver becomes the target of multiple hits leading to non-alcoholic steatohepatitis (NASH), the histological phenotype that may progressively lead to the development of liver fibrosis, cirrhosis and possibly hepatocellular carcinoma.
The recent epidemic in chronic liver disease is related to the burden of Non-Alcoholic Fatty Liver Disease (NAFLD), paralleling the worldwide increase of obesity.  NAFLD is a complex condition related to metabolic derangements in insulin resistance (IR), but in a subset of patients the liver becomes the target of multiple hits leading to Non-Alcoholic SteatoHepatitis (NASH), the histological phenotype that may progressively develop liver fibrosis, cirrhosis and possibly hepatocellular carcinoma.
This article is protected by copyright. All rights reserved. PMID: 31278754 [PubMed - as supplied by publisher]
Authors: Ferrell JM, Chiang JYL Abstract Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity o...
CONCLUSION: Cholesterol overloads not only trigger hepatic damage, but also affect the gallbladder significantly. PMID: 31104801 [PubMed - in process]
ConclusionFurther research is urgently needed to evaluate NNS consumption and its relationship with NAFLD and the gut microbiome in humans.
Publication date: Available online 16 May 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Naga Swetha Samji, Rajanshu Verma, Sanjaya K. SatapathyAbstractThe incidence of NAFLD is continuing to rise worldwide and it is estimated that this disquieting trend will continue for another 10-15 years before prevalence begins to decrease. NAFLD is the hepatic manifestation of metabolic syndrome. As obesity, diabetes and other life style related diseases continue to rise, the spectrum of NAFLD e.g., NASH (nonalcoholic steatohepatitis), liver fibrosis, liver cirrhosis, liver related morbidity and mortality will ...
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