Simple Noninvasive Scores Are Clinically Useful to Exclude, Not Predict, Advanced Fibrosis: A Study in Turkish Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease.

Conclusions: The main clinical utility of the FIB-4 and NFS in patients with NAFLD lies in the ability to exclude, not identify, advanced fibrosis. PMID: 31530739 [PubMed - as supplied by publisher]
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research

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Publication date: Available online 20 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sutapa Sarkar, Firas Alhasson, Diana Kimono, Muayad Albadrani, Ratanesh K. Seth, Shuo Xiao, Dwayne E. Porter, Geoff I. Scott, Bryan Brooks, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh ChatterjeeAbstractNAFLD often results in cardiovascular, intestinal and renal complications. Previous reports from our laboratory highlighted NAFLD induced ectopic inflammatory manifestations in the kidney that gave rise to glomerular inflammation. Extending our studies, we hypothesized that existing inflammatory conditions in NAFLD...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
ConclusionRFM-defined obesity better predicted dyslipidemia and hypertension (though not IR) and adipokine imbalance; however, it did not add value to BMI-defined obesity in predicting NAFLD or liver injury.
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
CONCLUSIONS: These data provide health care providers with predicted ranges of liver enzymes in patients with hepatocellular or cholestatic liver disease and may thereby help to identify patients with concurrent forms of liver disease. PMID: 31628070 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Authors: Polyzos SA, Hawa G, Jungwirth T, Karabouta Z, Kountouras J PMID: 31628635 [PubMed - as supplied by publisher]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Ceramide plays pathogenic roles in nonalcoholic fatty liver disease (NAFLD) via multiple mechanisms, and as such inhibition of ceramide de novo synthesis in the liver may be of therapeutically beneficial in pa...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
AbstractObjectiveTo evaluate the association between high uric acid (UA), reduced estimated glomerular filtration rate (eGFR), and non-alcoholic fatty liver disease (NAFLD) in outpatient children and adolescents with overweight (OW) or obesity (OB).MethodsAnthropometric, biochemical, hepatic ultrasound and eGFR data were available from 2565 young people with OW/OB (age 5 –18 years). eGFR was calculated using the Schwartz’s bedside formula and reduced eGFR (ReGFR+) was defined by a value  
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Authors: Marjot T, Moolla A, Cobbold JF, Hodson L, Tomlinson JW Abstract Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple steatosis, through to inflammation and fibrosis with a significant risk for the development of cirrhosis. It is highly prevalent and is associated with significant adverse outcomes both through liver-specific morbidity and mortality, but perhaps more importantly, through adverse cardiovascular and metabolic outcomes. It is tightly associated with type 2 diabetes and obesity and both of these conditions drive progressive disease towards the more advanced s...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
Publication date: Available online 21 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Shivaram P. Singh, Rakesh K. BarikNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. NAFLD encompasses a spectrum of disease ranging from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. However, despite the growing recognition of this important disease burden, there are significant challenges to accurately and noninvasively diagnose the various forms of NAFLD, especially to differentiate benign steatosis from t...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
ConclusionHCV treatment in a large community-based cohort demonstrated sustained improvements in AST, ALT, PLT, and FIB-4. Rebound increases in AST, ALT, and FIB-4 observed in Hispanics and those with BMI>30 kg/m2 may reflect persisting nonalcoholic fatty liver disease.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
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