Surviving Telomere Attrition with the MiDAS Touch.

Surviving Telomere Attrition with the MiDAS Touch.
Trends Genet. 2019 Sep 13;:
Authors: Flynn RL, Heaphy CM
Abstract
Cancer cells maintain telomere lengths through telomerase activity or by alternative lengthening of telomeres (ALT). Using an engineered model system, a recent study by Min et al. reveals that the combination of BLM-mediated DNA resection and telomere clustering, a characteristic of ALT telomeres, catalyzes RAD52-dependent mitotic DNA synthesis (MiDAS) specifically at telomeres to drive ALT activity.
PMID: 31526614 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - September 12, 2019 Category: Genetics & Stem Cells Authors: Flynn RL, Heaphy CM Tags: Trends Genet Source Type: research