Sudan: 15 New Suspected Cholera Cases in Blue Nile State

[Radio Dabanga] ED Damazin -The Blue Nile Doctors Committee reported 15 new suspected cholera cases in various localities of Blue Nile state.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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[Dalsan Radio] The Ministry of Health of Somalia has announced 145 new suspected cases of cholera, with one death reported, for epidemiological week 2 (6-12 January 2020). The cumulative total number of suspected cholera cases since the beginning of this outbreak is 10 113, including 51 associated deaths. So far in 2020, active transmission has been reported from Banadir and Lower Shebelle regions. Of the 145 cases reported during this week, 79% of the cases (114) are children under 5 years of age.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Source: Active Learning Network for Accountability and Performance in Humanitarian Action (ALNAP). Published: 1/17/2020. This 41-page paper aims to inform future humanitarian responses to epidemics or in contexts of an epidemic by drawing lessons for humanitarian practitioners from the responses to Ebola and cholera epidemics since 2010. It details nine lessons to limit the number of cases and deaths, and three lessons to limit the spillover effects of epidemics. It discusses how epidemics are happening more frequently and taking more lives in contexts where humanitarian actors operate. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Source: ScienceNOW - Category: Science Authors: Tags: twis Source Type: news
[Nyasa Times] Chances that there could be a serious outbreak of waterborne diseases in the northern region city of Mzuzu are high as officials have confessed that they have no waste management facilities, Nyasa Times can reveal.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[East African] It was a tumultuous year, research scientists say of 2019, as they point to cholera that swept through Mozambique, threatening the population just as the protracted Ebola crisis hit the Democratic Republic of Congo.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Soft Matter, 2020, Accepted Manuscript DOI: 10.1039/C9SM01913H, PaperMartin Berg Klenow, Jonas Camillus Jeppesen, Adam Simonsen Membrane curvature effects are important in numerous cellular processes and many membrane interacting proteins induce spontaneous curvature upon membrane binding. Shiga and cholera toxins both belong to the AB5 family... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins that translocate multiple functionally independent effector domains into a target eukaryotic cell. Vibrio cholerae colonizes intestinal epithelial cells (IECs) and uses a MARTX toxin with three effector domains—an actin cross-linking domain (ACD), a Rho inactivation domain (RID), and an α/β hydrolase domain (ABH)—to suppress innate immunity and enhance colonization. We investigated whether these multiple catalytic enzymes delivered from a single toxin functioned in a coordinated manner to suppress intesti...
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Research Articles Source Type: news
Abstract Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins that translocate multiple functionally independent effector domains into a target eukaryotic cell. Vibrio cholerae colonizes intestinal epithelial cells (IECs) and uses a MARTX toxin with three effector domains-an actin cross-linking domain (ACD), a Rho inactivation domain (RID), and an α/β hydrolase domain (ABH)-to suppress innate immunity and enhance colonization. We investigated whether these multiple catalytic enzymes delivered from a single toxin functioned in a coordinated manner to suppress i...
Source: Science Signaling - Category: Biomedical Science Authors: Tags: Sci Signal Source Type: research
DiscussionExpanding the treatment of acute watery diarrhoea in high-risk children to include an antibiotic may offer an opportunity to reduce deaths. These benefits may result from direct antimicrobial effects on pathogens or other incompletely understood mechanisms including improved nutrition, alterations in immune responsiveness or improved enteric function. The expansion of indications for antibiotic use raises concerns about the emergence of antimicrobial resistance both within treated children and the communities in which they live. ABCD will monitor antimicrobial resistance. The ABCD trial has important policy impli...
Source: Trials - Category: Research Source Type: clinical trials
Abstract The Republic of Zambia declared a cholera outbreak in Lusaka, the capital, on October 6, 2017. By mid-December, 20 of 661 reported cases had died (case fatality rate 3%), prompting the CDC and the Zambian Ministry of Health through the Zambia National Public Health Institute to investigate risk factors for cholera mortality. We conducted a study of cases (cholera deaths from October 2017 to January 2018) matched by age-group and onset date to controls (persons admitted to a cholera treatment center [CTC] and discharged alive). A questionnaire was administered to each survivor (or relative) and to a family...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
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