Molecules, Vol. 24, Pages 3399: Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms

Molecules, Vol. 24, Pages 3399: Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms Molecules doi: 10.3390/molecules24183399 Authors: Ashutosh Gupta Amit Kumar Singh Ramesh Kumar Risha Ganguly Harvesh Kumar Rana Prabhash Kumar Pandey Gautam Sethi Anupam Bishayee Abhay K. Pandey Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one of the major bioactive compounds present in various plants. Ellagitannins belong to the hydrolyzable tannins, a group of polyphenols. Corilagin shows broad-spectrum biological, and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, and antitumor actions. Natural compounds possessing antitumor activities have attracted significant attention for treatment of cancer. Corilagin has shown inhibitory activity against the growth of numerous cancer cells by prompting cell cycle arrest at the G2/M phase and augmented apoptosis. Corilagin-induced apoptosis and autophagic cell death depends on production of intracellular reactive oxygen species in breast cancer cell line. It blocks the activation of both the canonical Smad and non-canonical extracellular-signal-regulated kinase/Akt (protein kinase B) pathways. The potential apoptotic action of corilagin is mediated by altered expression of procaspase-3, procaspase-8, procaspase-9, poly (ADP ribose) polymerase, and Bcl-2 Bax. In nude mice, corilagin suppressed cholangi...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research