Complement inhibitors are useful in secondary hemolytic uremic syndromes

The term hemolytic uremic syndrome (HUS) encompasses 3 different entities: typical HUS caused by a shiga toxin –producing Escherichia coli, primary atypical HUS (aHUS) resulting from the dysregulation of the complement alternative pathway, and secondary HUS caused by a variety of etiologies whose common characteristic is to induce diffuse endothelial damage leading to thrombotic microangiopathy (TMA). As s hown in Supplementary Table S1, the most common causes of secondary HUS are drugs, infections, autoimmune diseases, malignancies, and hematopoietic stem cell transplantation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Controversies in Nephrology Source Type: research

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ConclusionsThe experience of changes in taste was common yet highly variable in its presentation and resultant changes in food preferences. Taste changes did not always resolve soon after treatment completion. Future research should identify ways to manage this symptom in pediatric cancer patients.
Source: Quality of Life Research - Category: Health Management Source Type: research
We present two cases in which endovascular and bypass repairs occluded and the limbs were at risk of amputation.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
CONCLUSIONS: These data provide health care providers with predicted ranges of liver enzymes in patients with hepatocellular or cholestatic liver disease and may thereby help to identify patients with concurrent forms of liver disease. PMID: 31628070 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 19 October 2019Source: Autoimmunity ReviewsAuthor(s): David S. Pisetsky, Xavier Bossuyt, Pier Luigi MeroniAbstractSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease with highly variable clinical and immunological manifestations. In the classification of patients with this condition, the presence of an antinuclear antibody (ANA) is an important element, with new criteria from the American College of Rheumatology and European League against Rheumatism positioning ANA positivity by an immunofluorescence assay on HEp2-cells (HEp2-IFA) or by an equivalent solid phase assay a...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 19 October 2019Source: Stem Cell ResearchAuthor(s): Marija Dulovic-Mahlow, Agnieszka Lukomska, Sokhna Haissatou Diaw, Alexander Balck, Max Borsche, Karen Grütz, Insa Lenz, Franziska Rudolph, Katja Lohmann, Christine Klein, Philip SeiblerAbstractDespite a genetic component in the development of Parkinson´s disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus a...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 19 October 2019Source: Stem Cell ResearchAuthor(s): Anja Ramme, Daniel Faust, Leopold Koenig, Uwe MarxAbstractFour integration-free iPSC lines were generated by reprogramming peripheral blood mononuclear cells with episomal vectors. All four human donors (two male and two female donors) belong to one Caucasian family within three different generations with the age between 19-82 years. Additionally, all iPSC lines are approved for commercial use by donor consent. Those iPSC lines offer the opportunity to study the influence of affiliation within one family. In future, more iPSCs lines of m...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 19 October 2019Source: Materials Science and Engineering: CAuthor(s): Camilo A.S. Ballesteros, Daniel S. Correa, Valtencir ZucolottoAbstractSmart nanomaterials activated by light is one of the most exciting strategies to control the release of substances in varied environments. Here we developed a smart nanomaterial formed by a photoresponsive nanogel containing silver nanoparticles (AgNPs) immobilized on the surface of biodegradable polycaprolactone (PCL) nanofibers mats produced by electrospinning. The silver nanoparticles (AgNps) are released from the nanogel and dispersed inside the n...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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