Immune correlates of the differing pathological and therapeutic effects of neoadjuvant chemotherapy in breast cancer

Conclusions: Increased NK cells after NAC, together with increased CD4+ and CD8+ T-cells, and decreased CTLA-4+ T cells and VEGF correlate with beneficial therapeutic effects. Systemic activation of pNK cell activity and the presence of pre-NAC TILs may improve the elimination of Ax + together with decreased immunosuppression by VEGF in tumors.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research