The Relationship Between Macrophages, Matrix Metalloproteinase-12, Interleukin-6, and Intraluminal Thrombus in Human Abdominal Aortic Aneurysms

We have previously shown that abdominal aortic aneurysm (AAA) rupture occurs in regions of low wall shear stress, where flow recirculation and intraluminal thrombus (ILT) deposition predominate. We planned to analyze differential matrix metalloproteinase (MMP)12, and interleukin (IL)-6 levels in human AAA tissue. We hypothesized that AAA with higher ILT will have greater macrophage-mediated elastolytic activity, thus, contributing to the differential in sides of the AAA that rupture.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts from the 2019 Canadian Society for Vascular Surgery Annual Meeting Source Type: research

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We report the presence of a giant aneurysm of the right coronary artery and giant ectasia of the left coronary system with active thrombosis in a man with history of an abdominal aortic aneurysm, with endovascular treatment and a non-ST segment elevation myocardial infarction with no reperfusion strategy, who required a coronary computed tomography, identifying the anatomical characteristics of this disease. PMID: 31588134 [PubMed - in process]
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
CONCLUSIONS: Our results indicate a role of AEBP1 in the pathogenesis of AAA and provide a novel insight into how AEBP1 causes the development of AAA by activating the NF-κB pathway. PMID: 31462616 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
ConclusionThe endovascular neck stabilization is a useful treatment option that facilitates standard EVAR for AAA in chronic aortic dissection.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
CONCLUSIONSSecond-stage endovascular repair after previous fET is feasible with good mid-term results. This staged hybrid procedure is extremely effective in patients whose aneurysms are confined both to the arch and thoraco-abdominal aorta leading to an excellent functional result. In case of favorable anatomy endovascular repair in residual type B aortic dissection lead to complete false lumen thrombosis.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We examined the relationship between preoperative spatial morphology of ILT and the incidence of postoperative T2E.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research, Basic Science Source Type: research
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Jose Luis Martin-Ventura, Diego Martinez-Lopez, Raquel Roldan-Montero, Carmen Gomez-Guerrero, Luis Miguel Blanco-ColioAbstractCardiovascular diseases (CVD) remain the major cause of morbidity and mortality in Europe. The clinical complications associated to arterial wall rupture involve intimal cap rupture in complicated atherosclerotic plaques and medial rupture in abdominal aortic aneurysm (AAA). The mechanisms underlying pathological vascular remodeling include lipid accumulation, cell proliferation, redox imbalance, proteolysis, leukocyte ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Rationale: Abdominal aortic aneurysm is an extremely rare cause of deep vein thrombosis. Here we report an elderly gentleman who presented with deep vein thrombosis and was found to have concomitant abdominal aortic aneurysm upon ultrasonographic screening. It illustrates the possibility of such an aetiology, and the importance of screening for such aneurysms in a select patient population before heparinization. Patient concerns: A 73-year-old Asian gentleman with underlying hypertension, hyperlipidaemia, chronic renal failure, and history of chronic smoking presented to the emergency department with acute left lower ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA) of a size warranting consideration for surgical or endovascular intervention. The rupture risk of AAAs is thought to be related to the balance of vessel wall strength and the mechanical stress caused by systemic blood pressure. Previous finite element analyses of AAAs have shown that ILT can reduce and homogenize aneurysm wall stress. These works have largely considered ILT to be homogeneous in mechanical character or have idealized a stiffness distribution through the thrombus thickness. In this work, we use magnetic resonance imagi...
Source: Journal of Biomechanical Engineering - Category: Biomedical Engineering Source Type: research
Abstract Objective: The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways. Methods: We enrolled 38 patients with ≥ 45 years old undergoing surgery for abdominal aortic aneurysm or peripheral artery disease under general or regional anesthesia and who were hospitalized at least one night after the procedure. Patients undergoing carotid artery surgery and those who had acute bypass graft thrombosis, cancer, renal failure defined as estimated glomerular filtration rate
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Beh çet disease is a multisystem disorder presenting with recurrent oral and genital ulcerations as well as with ocular involvement. Vascular involvement can occur in up to 50% of affected patients. Arterial aneurysms are often multiple and are characterized by a saccular configuration with increased r isk of unexpected rupture, thrombosis, and aneurysm recurrence. Here we report a case of giant infrarenal abdominal aortic aneurysm in a 34-year-old man with Behçet disease who underwent aneurysmorrhaphy and aortobifemoral bypass.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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