Discovery of a New Biomarker Pattern for Differential Diagnosis of Acute Ischemic Stroke Using Targeted Metabolomics

Stroke is one of the leading causes of disability all over the world. However, biomarkers for fast differential diagnosis of acute ischemic stroke (AIS) from vertigo or headache, remains lacking. Using a direct-infusion mass spectrometry method, it is possible to establish an efficient method for AIS differential diagnosis that requires only a few minutes. Thirty-eight clearly diagnosed AIS patients and 46 patients with a main complaint of vertigo were enrolled in this study. There was a total of 58 metabolites that were measured by our targeted metabolomics method, and the data were analyzed by pattern recognition algorithms. As a result, a clear classification between AIS and vertigo patients was achieved. Acylcarnitines are the major discriminating metabolites between the two groups. Arginine and its ratio, which is related to urea cycle metabolites, including arginine/ornithine and citrulline/arginine, also accounted for the classification. Interestingly, the levels of these metabolites were also found to be restored among recovering AIS patients (n = 11), which indicated that the metabolic alterations are possibly related to AIS development. Based on the characters from the data pattern reorganization, a novel biomarkers pattern was established using a binary logistic model, which contained arginine, arginine/ornithine, vaccenylcarnitine, and hydroxylbutyrylcarnitine. This biomarkers pattern achieved an area under the receiver operating characteristic curve of 0.89 for t...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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ConclusionWe have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research.
Source: NeuroImage - Category: Neuroscience Source Type: research
Authors: Bashir MU, Bhagra A, Kapa S, McLeod CJ Abstract Atrial fibrillation is the most common symptomatic arrhythmia that is associated with stroke. Contemporary management of the disease is focused on anticoagulation to prevent stroke, coupled with catheter ablation to limit symptoms and prevent deleterious cardiac remodeling. Emerging data highlights the importance of lifestyle modification by managing sleep apnea, increasing physical activity, and weight loss. There is significant data that supports a link between the autonomic nervous system, arrhythmia development, and atrial fibrillation therapy. It is like...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
Publication date: Available online 12 October 2019Source: Journal of Sound and VibrationAuthor(s): M. Dal Borgo, M. Ghandchi Tehrani, S.J. ElliottAbstractThis paper presents a theoretical and experimental study of a stroke limited inertial actuator when used for active vibration control. The active control system under investigation consists of the inertial actuator attached to a flexible structure, a collocated vibration sensor and a velocity feedback controller (VFC). Controlling low frequency motions or large amplitude vibrations requires a very long stroke for the proof mass. However, a physical limitation of inertial ...
Source: Journal of Sound and Vibration - Category: Physics Source Type: research
CONCLUSION: LZT treatment appears to be a feasible, non-pharmacological therapy amenable to SMs. Results from this pilot study promote further investigation of LZT as an intervention for SMs with persistent symptoms following TBI. PMID: 31603218 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Publication date: Available online 12 October 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Masahiko Mukaino, Birgit Prodinger, Yuki Okouchi, Kouji Mizutani, Yuki Senju, Megumi Suzuki, Eiichi SaitohAbstractBackground: Modification of the home environment, together with rehabilitative interventions, is important for maximizing the level of functioning after an individual with disability undergoes rehabilitation in the hospital.Objectives: We developed a simple screening scale — the home environment checklist (HEC) — to identify any mismatch between an individual’s abilities and their...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Authors: Saraceno B Abstract Global mental health (GMH) seems to enjoy increasing visibility in the global health and development discourse. However, this visibility implies also the urgency of addressing few questions about new priority setting in the domains of policy, care delivery, service organisation and research. Even before trying to answer these questions, rethinking more deeply the notion and implications of GMH seems to be a useful collective exercise. Some unanswered questions should be at the core of this exercise: Is GMH really global or rather Western? Is GMH concerned enough with local context? Is G...
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
{ "imageBrowse": "", "imageCaption": "", "imageCredit": "", "question": " ... Recent research found that a substantial loss of income can raise the risk of heart attack and stroke. ... Is the follo...
Source: AARP.org News - Category: American Health Source Type: news
Authors: Horta-Baas G, Peláez-Ballestas I, Queipo G, Montero Hernández U, Romero-Figueroa MDS Abstract OBJECTIVES: Alexithymia is a personality trait related to the quality of life of women with fibromyalgia (FM). It is still unknown whether alexithymia is associated with the clinical manifestations of FM. The present study describes the relationship between alexithymia and the domains included in the core set recommended by the Outcome Measures in Rheumatology (OMERACT) for FM evaluation. METHODS: One hundred two women with FM were enrolled in the cross-sectional study. The domains evaluated were...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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