Hereditary Features of Bipolar Disorder.

Hereditary Features of Bipolar Disorder. Prim Care Companion CNS Disord. 2019 Sep 12;21(5): Authors: Côrte-Real B, Andrade G, Pestana PC, Duarte TA, Martins PT PMID: 31529809 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

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In this study, we investigated the interrelations among interleukin (IL)-6 cytokine level, grey matter (GM) volume of the anterior cingulated cortex (ACC), and attention function among offspring of parents diagnosed with BD. The offspring were categorized as being either asymptomatic or symptomatic based on whether they manifested pre-defined sub-threshold mood symptoms. We found that the symptomatic offspring showed significantly higher serum levels of IL-6 than the asymptomatic offspring (F (1, 59) = 67.65, p0.05). Mediation analyses revealed that the GM volume of the rostral ACC significantly mediated the negative assoc...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
ConclusionsThe current rapid, multi-slice acquisition and real-time implementation of temperature and displacement visualization may be useful in clinical practices. It may help defining operational safety margins, improving therapy precision and efficacy. Simulations were in good agreement with experimental data and may thus be used prior treatment for procedure planning.
Source: NeuroImage - Category: Neuroscience Source Type: research
We examined the concentrations of chemokines and related substances in the brain tissue from these two groups using the Bio-Plex Pro™ Human Chemokine Panel 40-Plex. We performed multiple regression analysis with covariates. The levels of CCL1, CCL8, CCL13, CCL15, CCL17, CCL19, CCL20, CXCL11, and IL-10 were significantly decreased, whereas the IL-16 levels were significantly increased in the suicide completers after adjustment with the Benjamini-Hochberg method to control for type Ⅰ errors (Q 
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
CONCLUSION: Despite good interrater variability and convenient usage of the suggested X‑ray assessment system, this approach did not enable the identification of any associations by which a TM and, therefore, a possible straightforward or complicated treatment pathway could be predicted. Attention should possibly be paid to a rotation of the cuff during implantation with a lateral position of the stimulation lead. PMID: 31598770 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 147Author(s): Kangguang Lin, Tao LiuAbstractPeople with Bipolar disorder (BD) often have a sedentary lifestyle and low level of physical activity which in part contribute to the high co-occurrence of medical diseases including cardiovascular disease, type 2 diabetes, and metabolic syndrome, etc. Exercise especially aerobic exercise may be beneficial not only to mental health but also physical health outcomes. Targeting barriers for exercise such as high BMI and making the best use of facilitators (e.g., concept of fitness) can result in higher level...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
This study determines the relationship between cognition and vascular burden in patients with SMD. Methods: Sixty SMD patients (61% men, mean age: 46) attending a psychosocial rehabilitation centre were included. We evaluated sociodemographic, clinical, laboratory, quality of life and functionality characteristics. And we analysed the association between cognitive performance and vascular burden. Results: SMD diagnoses were: 41.7% schizophrenia, 20.0% bipolar, 5.0% schizoaffective, 21.7% depressive and 11.7% other. Cognitive impairment was present in 55% of the cases. The average vascular burden was 3.2. Patients with cogn...
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
ConclusionThis case highlights the importance of maintaining a high index of suspicion when encountering psychiatric patients with nonspecific lower abdominal or anorectal pain with inconsistent presentations. Controversy exists regarding the type of surgical treatment in case of anorectal perforation. More research is needed to provide surgeons with evidence-based standardized methods for dealing with these rare pathologies.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Conclusions: Our results indicate a potential mismatch between cerebral blood supply and oxygen metabolism in BD, suggesting inefficiency in energy homeostasis in the brain. Mapping CMRO2 would provide the spatial resolution to investigate regional alterations in metabolism, particularly in the brain regions where CBF is increased.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study reports the design, synthesis, and characterization of two new bipolar host materials, DCzCP and TCzCP. Both materials were implemented as hosts by doping a known green thermally activated delayed fluorescent (TADF) emitter (t4CzIPN) in solution-processable OLEDs. DCzCP-based devices afford the best performance with the maximum external quantum efficiency (EQE) of 21.2%. Notably, the EQE was maintained at 20.7% and 19.7% at a practical luminance of 500 cd m-2 and 1000 cd m-2, respectively, demonstrating very small roll-off. PMID: 31602441 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
This article suggests that systems biology, emphasizing the epigenetic component of systems biology, could help identify clinically useful biomarkers in neuropsychiatric disorders like SZ, BD, and MDD.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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