A Death from Consuming 'Alcohol'

BY ​MICHELE STYBEL; LAURIE-ANN ANTOINE; JENNIFER TUONG; AHMED RAZIUDDIN, MDA 54-year-old man with a past medical history of COPD presented to the ED with shortness of breath that had started an hour earlier. He was alert and oriented, but also agitated, combative, and unable to provide an adequate history.He said he was a heavy smoker and drinker and that he had been smoking and consuming alcohol when the symptoms started. He also reported past Cannabis use.He was in acute respiratory distress with BiPAP in place, restless, and diaphoretic. Respiration was labored with bilateral expiratory wheezing but no significant cardiac and abdominal findings. His vital signs were normal except for an elevated respiratory rate of 32 bpm. His pulse oximetry was 91% on 100% FiO2.Lab tests revealed a lactic acid of 10 mmol/L. An arterial blood gas analysis revealed a pH of 6.95 and HCO3 of 7.2 mEq/L. The most likely differentials were ethylene glycol or methanol ingestion. His methanol level was 136 mg/dL, so methanol poisoning was identified as the cause. He was also diagnosed with anion gap metabolic acidosis and acute exacerbation of chronic obstructive airway disease. Sodium bicarbonate and fomepizole were given.Rapid DeteriorationHe developed acute respiratory failure about three hours later, and was unresponsive and then intubated. His blood pressure in the ICU began trending down, and his mean arterial pressure was consistently below 65 mm Hg with fluid resuscitation...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research

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In this study, platinum electrodes were fabricated on the bio-based poly(ethylene terephthalate) (Bio-PET) substrates for the development of flexible electrochemical sensors for the detection of Parkinson's disease biomarkers. Dopamine was detected by voltammetric measurements, displaying a 3.5 × 10−5 mol L−1 to 8.0 × 10−4 mol L−1 linear range with a limit of detection of 5.1 × 10−6 mol L−1. Parkinson's disease protein 7 (PARK7/DJ-1) was successfully detected by electrochemical impedance spectroscopy after elec...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 20 January 2020Source: Carbohydrate PolymersAuthor(s): Sheng Xu, Si-Yu Li, Min Zhang, Hong-Yan Zeng, Kun Wu, Xian-Yao Tian, Chao-Rong Chen, Yong PanAbstractAn efficient and bio-based alginate pillared hydrotalcite (SA@LDHs) was fabricated via calcination-reconstruction manner with sodium alginate (SA) and hydrotalcite (LDHs-C), and used as novel flame retardant for polypropylene (PP). The morphologies and combustion properties of SA@LDHs and its hybrid with PP composites (PP/SA@LDHs) had been characterized by SEM, TGA, cone calorimetry, LOI and UL-94 measurements. With 30 wt% loadi...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Increases in the number of cell therapies in the preclinical and clinical phases have prompted the need for reliable and noninvasive assays to validate transplant function in clinical biomanufacturing. We developed a robust characterization methodology composed of quantitative bright-field absorbance microscopy (QBAM) and deep neural networks (DNNs) to noninvasively predict tissue function and cellular donor identity. The methodology was validated using clinical-grade induced pluripotent stem cell–derived retinal pigment epithelial cells (iPSC-RPE). QBAM images of iPSC-RPE were used to train DNNs that predicted iPSC-...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The advent of human induced pluripotent stem cells (iPSCs) provided a means for avoiding ethical concerns associated with the use of cells isolated from human embryos. The number of labs now using iPSCs to generate photoreceptor, retinal pigmented epithelial (RPE), and more recently choroidal endothelial cells has grown exponentially. However, for autologous cell replacement to be effective, manufacturing strategies will need to change. Many tasks carried out by hand will need simplifying and automating. In this issue of the JCI, Schaub and colleagues combined quantitative brightfield microscopy and artificial intelligence...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: International Journal of Environmental Analytical Chemistry - Category: Chemistry Authors: Source Type: research
Authors: Borrego Garcia E, Ruiz Sancho AL, Plaza Lara E, Díaz Gómez L, Delgado Ureña A PMID: 31955900 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Authors: Valga F, Monzón T, Henriquez F, Anton-Pérez G PMID: 31955899 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
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Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
In this study, we report the surface defect formation of annealed poly(pyromellitic dianhydride-co-4,4′-oxydianiline) (PMDA-ODA) film after detaching the film from soda-lime glass via ion migration. The defect was porous and sodium was observed as one of the major impurities in the defect. We propose that these defects form as a result of the ion migration from glass and thermal decomposition of PMDA-ODA. The ions released from glass at a sufficiently high temperature form hydroxide compounds during the floating of the film on water and readily attacks the imide ring at the glass-film interface. The ionic bonds are b...
Source: Polymer Degradation and Stability - Category: Chemistry Source Type: research
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