Appraisal of Non-Cardiovascular Safety for Sodium –Glucose Co-Transporter 2 Inhibitors: A Systematic Review and Meta-Analysis of Placebo-Controlled Randomized Clinical Trials

Background: Whereas the cardiovascular safety of sodium-glucose co-transporter 2 (SGLT2) inhibitors has been well reported, there is limited data from controlled clinical trials regarding the non-cardiovascular safety. This was the focus of our study.Methods and Findings: We systematically searched MEDLINE, EMBASE, and Cochrane Library (5th Sep 2018) for randomized controlled trials (RCTs) that reported safety data for SGLT2 inhibitors and placebo. Relative risks (RRs) and their 95% confidence intervals (CIs) were pooled using random-effects models. Seventy RCTs (83 studies enrolling 36,958 patients in 78 publications) were identified. SGLT2 inhibitors were associated with a lower risk of serious adverse events (RR 0.90, 95% CI 0.86 to 0.94, P
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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The purpose of this study was to evaluate the relationship between the circadian profile of the vasorelaxing substances calcitonin gene-related peptide (CGRP) and epoxyeicosatrienoic acids (EETs) and the vasconstrictive agent endothelin-1 (ET1) and the daily rhythms of cardiac hemodynamic indices (CHI) and baroreflex (BRS) in Wistar rats with 1 kidney-1 clip model of arterial hypertension (1K-1C AH). The animals were divided into 3 groups: I- sham-operated (SO), II- 4-week and III- 8-week 1K-1C AH rats. Plasma concentration of ET1, CGRP and EET ’s were investigated every 4 h. In conscious freely moving 1K-1C AH rats ...
Source: Journal of Circadian Rhythms - Category: Biology Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ04331D, PaperLorena Portela Brazuna, Thiago Galeoti Tabuti, Adrielle de Paula Silva, Dayana Tada, M ário José Politi, Rebeca Bacani, Eduardo Rezende Triboni ZnO nanoparticles having spherical and rod shapes with high crystallinity and uniform average crystallite sizes were prepared by the glycerol-urea route (GU). The syntheses were carried out using Zn(NOtext-decoration:underline"3)text-decoration:underline"2.6Htext-decoration:underline"2O and... The content of this RSS Feed (c) The Royal Society of Chemistry
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J. Mater. Chem. A, 2019, Advance Article DOI: 10.1039/C9TA08839C, PaperGanesh Kumar Veerasubramani, Myung-Soo Park, Goli Nagaraju, Dong-Won Kim Vertically-aligned interlayer-expanded MoS2@C@MoS2 can be a potential anode material for sodium-ion batteries with good cycling performance. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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This study included SSc patients who underwent right heart catheterization (RHC) in our hospital during 2010–2018. Following variables were assessed for performance to predict mPAP ≥ 25 mmHg or >  20 mmHg; anti-centromere or U1-RNP antibody, plasma BNP level, serum urate level, right axis deviation, forced vital capacity (FVC)/diffusing capacity for carbon monoxide (DLCO) ratio, and tricuspid regurgitation velocity. Of 58 patients enrolled in this study, 24 had mPAP of ≥ 25 mmHg an d 9 had mPAP of 21–24 mmHg. Among variables tested, only FVC...
Source: Rheumatology International - Category: Rheumatology Source Type: research
First study of its kind to show that although low doses of statins appear protective of bone health, high doses may increase risk for osteoporosis.Medscape Medical News
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Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
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HIGH blood pressure is an insidious condition. Symptoms rarely show up until it is serious. Fortunately, overhauling one ’s diet can mitigate the risks. Research suggests drinking a certain fruit juice may do the trick.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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