ILC2s and Basophils Team Up to Orchestrate IL-33 –Induced Atopic Dermatitis

In this issue, Imai et al. (2019) provide new insights into the pathophysiology of AD-like inflammation using their model (Imai et al., 2013) and ask how ILC2s and basophils contribute to the IL-33 –induced AD-like inflammation. Their findings show that continuous expression of IL-33 in keratinocytes is sufficient to cause AD-like inflammation in mice, and that this occurrence is largely independent of adaptive immune cells and is mediated by basophils and ILC2s.

Source: Journal of Investigative Dermatology - September 19, 2019 Category: Dermatology Authors: Bernhard Ryffel, Jos é Carlos Alves-Filho Tags: Commentary Source Type: research