The prognostic significance of BCR-1 and BCR-3 isoforms of PML-RARA and FLT3-ITD in patients with acute promyelocytic leukemia

Conclusion; Age is an independent prognostic factor for APL. Bcr3 is significantly associated with FLT3-ITD in adult APL. DIC & FLT3-ITD are adverse prognostic factors in pediatric APL. Despite higher HR groups in pediatric patients, the outcome is better than adult patients.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research