Ecallantide: An Alternative Treatment of Refractory Angioedema in Adolescents with Systemic Lupus Erythematosus

Publication date: Available online 18 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Watcharoot Kanchongkittiphon, Nora Kabil, Leonard B. Bacharier, Maleewan Kitcharoensakkul
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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Hydroxychloroquine (HCQ, Plaquenil ®) is an antimalarial agent with immunosuppressive and cytotoxic properties that is considered safe and effective in pregnant patients with a history of mild lupus nephritis (LN).1-2 Hypersensitivity to hydroxychloroquine usually manifests as maculopapular exanthems within two to 33 days and rarely as eosinophilia or other systemic symptoms.3 Several prolonged desensitization protocols, ranging from four to 36 days in duration, have been proposed to manage prior histories of HCQ hypersensitivity.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as a...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
New classification criteria for systemic lupus erythematosus (SLE) from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) represent a"paradigm shift" in how the disease is diagnosed and studied, the developers say.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
AbstractSystemic lupus erythematosus (SLE) is a chronic, autoimmune disease associated with major obstetrical complications such as gestational loss, preterm delivery, fetal growth restriction (FGR) and preeclampsia. Published literature is not consensual regarding the main risk factors for each of these outcomes. Our goal with this study was to determine the most important predictors for each of the main adverse pregnancy outcomes in this population. We conducted a retrospective cohort study of unifetal pregnancies of women with the diagnosis of SLE followed in our unit between January 1994 and December 2016. We excluded ...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
AbstractDiffuse alveolar hemorrhage (DAH) is a rare but potentially deadly manifestation of systemic lupus erythematosus (SLE). The aim of this study was to investigate the clinical characteristics and risk factors of DAH in SLE. A systematic review and meta-analysis of previous observational studies compared the clinical characteristics and risk factors between DAH-SLE and SLE patients without DAH. A total of 5 observational studies were included in this meta-analysis. Compared with the SLE patients without DAH, DAH-SLE patients had a significantly higher incidence of neuropsychiatric events (OR  = 4.321, 95...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 16 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Naiya B. Patel, Lyda Cuervo-Pardo, Timothy L. Tan, Roopal V. Kundu, Sergio E. Chiarella
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Abstract Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase-positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus. Few reports have reported lupus erythematosus (LE) in patients with X-linked CGD (XL-CGD) and carriers, and very few in autosomal recessive CGD (AR-CGD). Here, we present 5 patients with CGD developing LE at different ages to emphasize on the importance of appropriate follow-up and treatment in pat...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research
Abstract The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified as an inducer of follicle-stimulating hormone secretion. Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - Category: Allergy & Immunology Authors: Tags: Research article Source Type: research
How does fatigue impact quality-of-life in patients with cutaneous lupus erythematosus and other skin-limited autoimmune diseases?The British Journal of Dermatology
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news
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