Mucosectomy disrupting enteric nervous system causes contraction and shrinkage of gastro-intestinal flaps: Potential implications for augmentation cystoplasty

Augmenting the bladder with a sero-muscular gastro-intestinal flap is a promising alternative approach aiming for a mucus-free bladder augmentation, however the contraction (shrinkage) of the flaps remains a major concern. Enteric nervous system (ENS) abnormalities cause a failure of relaxation of the intestinal muscle layers in motility disorders like Hirschsprung ’s disease and Intestinal Neuronal Dysplasia. In mammals, the submucosal enteric nervous plexus contains nitrergic inhibitory motor neurons responsible for muscle relaxation.

Source: Journal of Pediatric Urology - September 17, 2019 Category: Urology & Nephrology Authors: D ániel Urbán, Mahmoud Marei Marei, Dániel Hajnal, Gabriella Varga, Dániel Érces, Marietta Poles, Dániel Imre, Anikó Szabó, Raimondo Cervellione, Tamas Cserni Source Type: research