Differential pharmacology and clinical utility of dapagliflozin in type 2 diabetes

Source: International Journal of COPD - Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research

Related Links:

ConclusionThe use of PA breaks during sitting moderately attenuated post-prandial glucose, insulin, and TAG, with greater glycaemic attenuation in people with higher BMI. There was a statistically significant small advantage for PA breaks over continuous exercise for attenuating glucose measures when exercise protocols were energy matched, but no statistically significant differences for insulin and TAG. PROSPERO Registration: CRD42017080982.PROSPERO RegistrationCRD42017080982.
Source: Sports Medicine - Category: Sports Medicine Source Type: research
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Geriatrics II Source Type: research
AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high ‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, v asodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affe...
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research
ConclusionsOur findings suggest that patient teach-back method is associated with reduced risk of hospitalization for those with ACSCs, especially among patients with cardiovascular diseases and type 2 diabetes. Encouraging providers to utilize the teach-back method at every visit has the potential to further reduce hospitalizations for individuals with ACSCs.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Profits are shrinking at many U.S. healthcare systems. Their inpatient costs are increasing, while their admissions and revenues remain flat. In response, organizations are shifting their care-delivery strategies away from the costly inpatient setting to more cost-effective outpatient settings. Many companies see this shift and are investing to reflect it. However, simply labeling a product for outpatient use is not enough. In today’s value-based care environment, the bar for outpatient use is even higher than that for inpatient use. The shift in care delivery demands a shift in R&D and market...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Abstract Adenosine is a purine nucleoside, responsible for the regulation of a wide range of physiological and pathophysiological conditions by binding with four G-protein-coupled receptors (GPCRs), namely A1, A2A, A2B and A3 adenosine receptors (ARs). In particular, A1 AR is ubiquitously present, mediating a variety of physiological processes throughout the body, thus represents a promising drug target for the management of various pathological conditions. Agonists of A1 AR are found to be useful for the treatment of atrial arrhythmia, angina, type-2 diabetes, glaucoma, neuropathic pain, epilepsy, depression and ...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Pharm Des Source Type: research
Background: Whether human insulin may affect lung cancer risk requires investigation. Methods: All patients with a diagnosis of diabetes mellitus from 1996 to 2009 were enrolled from Taiwan’s National Health Insurance. An entry date was set on January 1, 2004 and 1,007,617 patients with type 2 diabetes mellitus diagnosed before 2004 were followed up for new-onset lung cancer until December 31, 2009. Incidence rates of lung cancer for never-users, ever-users and tertiles of three dose-response exposure parameters (i.e., time since starting insulin, cumulative dose and cumulative duration) were calculated. Adjusted ha...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
A 77-year-old man with a history of hypertension, type 2-diabetes and chronic obstructive pulmonary disease came to the Emergency Department of our hospital with visual impairment, agraphia and memory loss. Cranial computed tomography (CT) revealed a hypodense lesion in the left posterior parietal white matter (maximum diameter of 4.5  cm) with vasogenic oedema. He was admitted to hospital to complete study of the primary neoplasm for suspicion of brain metastases. On day 3 post-admission, brain magnetic resonance imaging showed three images that suggested brain metastases.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Source: International Journal of COPD - Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
More News: Chronic Obstructive Pulmonary | Dapagliflozin | Diabetes | Diabetes Type 2 | Drugs & Pharmacology | Endocrinology | Forxiga | Respiratory Medicine